3-[2-(adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-7-(3-o-tolyl-ureido)-heptanoic acid 2-trimethylsilanyl-ethyl ester

Base Information

Chemical Name:3-[2-(adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-7-(3-o-tolyl-ureido)-heptanoic acid 2-trimethylsilanyl-ethyl ester
CAS No.:290310-68-8
Molecular Formula:C₄₃H₆₁N₅O₆Si
Molecular Weight:772.073
Hs Code.:

3-[2-(adamantan-2-yloxycarbonylamino)-3-(1<i>H</i>-indol-3-yl)-2-methyl-propionylamino]-7-(3-<i>o</i>-tolyl-ureido)-heptanoic acid 2-trimethylsilanyl-ethyl ester

Synonyms:3-[2-(adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-7-(3-o-tolyl-ureido)-heptanoic acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of 3-[2-(adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-7-(3-o-tolyl-ureido)-heptanoic acid 2-trimethylsilanyl-ethyl ester

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Technology Process of 3-[2-(adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-7-(3-o-tolyl-ureido)-heptanoic acid 2-trimethylsilanyl-ethyl ester

There total 7 articles about 3-[2-(adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-7-(3-o-tolyl-ureido)-heptanoic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 130406-40-5
N-[(2-adamantyloxy)-carbonyl]-α-methyl-R-tryptophane

: 290310-72-4
H-βHly(Tac)-TMSE

: 290310-68-8
3-[2-(adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-7-(3-o-tolyl-ureido)-heptanoic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(00)00198-0

Reference yield:

: 13734-28-6
Boc-Lys-OH

: 290310-68-8
3-[2-(adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-7-(3-o-tolyl-ureido)-heptanoic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 60 percent / dimethylformamide

2: TEA / tetrahydrofuran

4: 40 percent / PhCO₂Ag; TEA

5: 100 percent / HCO₂H

6: 54 percent / HBTU; DIPEA; acid / dimethylformamide

With formic acid; TEA; silver benzoate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Addition / 2: Acylation / 3: Substitution / 4: Rearrangement / 5: acidolysis / 6: Condensation;
DOI:10.1016/S0960-894X(00)00198-0

Reference yield:

: 614-68-6
2-tolyl isocyanate

: 290310-68-8
3-[2-(adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-7-(3-o-tolyl-ureido)-heptanoic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 60 percent / dimethylformamide

2: TEA / tetrahydrofuran

4: 40 percent / PhCO₂Ag; TEA

5: 100 percent / HCO₂H

6: 54 percent / HBTU; DIPEA; acid / dimethylformamide

With formic acid; TEA; silver benzoate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Addition / 2: Acylation / 3: Substitution / 4: Rearrangement / 5: acidolysis / 6: Condensation;
DOI:10.1016/S0960-894X(00)00198-0