(R)-1-PHOSPHONO-3-METHYL-BUTYLAMINE

Base Information

Chemical Name:(R)-1-PHOSPHONO-3-METHYL-BUTYLAMINE
CAS No.:88081-77-0
Molecular Formula:C5H14 N O3 P
Molecular Weight:167.145
Hs Code.:
Mol file:88081-77-0.mol

Synonyms:Phosphonicacid, (1-amino-3-methylbutyl)-, (R)-; (R)-Phospholeucine; L-Phospholeucine

Suppliers and Price of (R)-1-PHOSPHONO-3-METHYL-BUTYLAMINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(R)-1-AMINO(3-METHYLBUTYL)PHOSPHONIC ACID 95.00%
10G
$ 1334.03

Total 5 raw suppliers

Chemical Property of (R)-1-PHOSPHONO-3-METHYL-BUTYLAMINE

Chemical Property:

Melting Point:275 - 278 °C
PSA：93.36000
LogP:1.19530

Purity/Quality:

98% ^*data from raw suppliers

(R)-1-AMINO(3-METHYLBUTYL)PHOSPHONIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-1-PHOSPHONO-3-METHYL-BUTYLAMINE

There total 5 articles about (R)-1-PHOSPHONO-3-METHYL-BUTYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 104513-35-1
1-(N-Phenylacetylamino)-3-methylbutylphosphonic acid

: 20459-60-3,37100-69-9,88081-76-9,88081-77-0
L-1-Amino-3-methylbutylphosphonic acid

: 104513-35-1
D-1-(N-Phenylacetylamino)-3-methylbutylphosphonic acid

Guidance literature:: With potassium hydroxide; phosphate buffer; In water; for 24h; Ambient temperature; penicillin acylase (EC 3.5.1.11), pH 6.8-7.0;
DOI:10.1016/S0040-4020(01)86439-5

Reference yield: 45.0%

: 104513-35-1
1-(N-Phenylacetylamino)-3-methylbutylphosphonic acid

: (S)-1-(N-phenylacetylamino)-3-methylbutylphosphonic acid

: 88081-77-0
L-Leucine phosphonate

Guidance literature:: With penicillin G acylase from Escherichia coli immobilized on mesoporous Santa Barbara Amorphous; In aq. phosphate buffer; at 25 ℃; for 48h; pH=7; stereospecific reaction; Resolution of racemate; Enzymatic reaction;
DOI:10.1016/j.tetasy.2016.11.007

Reference yield:

: 65415-00-1
N-phenylacetyl-D,L-leucine

: (S)-1-(N-phenylacetylamino)-3-methylbutylphosphonic acid

: 88081-77-0
L-Leucine phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 10 °C / Electrolysis

1.2: 0.5 h / 20 °C

1.3: 4 h / 60 °C

2.1: water; hydrogenchloride / acetone / 4 h / Reflux

3.1: penicillin G acylase from Escherichia coli / aq. phosphate buffer / 23 h / 25 °C / pH 7 / Enzymatic reaction

With hydrogenchloride; methanol; penicillin G acylase from Escherichia coli; water; In aq. phosphate buffer; acetone;
DOI:10.1016/j.molcatb.2016.05.011