Technology Process of 3-(1'-benzoyl-5',6'-dimethoxy-3'-indolinyl)propanoic acid
There total 4 articles about 3-(1'-benzoyl-5',6'-dimethoxy-3'-indolinyl)propanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 91 percent / 40percent Triton B / ethanol; dioxane; methanol / 1.) 2.5h, 80-85 deg C, 2.) 40-50 deg C
2: 78 percent / H2 / 10percent Pd/C / ethyl acetate / 3 h / 80 °C
3: 87.6 percent / NaOH / dioxane; H2O / 2 h / Heating
4: borane-pyridine complex, 12.5percent HCl; 2.) aq. NaOH / 1.) methanol, ice-water bath, 25 min, then 4h, then 20-30 min; 2.) 1h
With
hydrogenchloride; sodium hydroxide; borane pyridine; hydrogen; N-benzyl-trimethylammonium hydroxide;
palladium on activated charcoal;
In
1,4-dioxane; methanol; ethanol; water; ethyl acetate;
DOI:10.1016/S0040-4020(01)98949-5
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 78 percent / H2 / 10percent Pd/C / ethyl acetate / 3 h / 80 °C
2: 87.6 percent / NaOH / dioxane; H2O / 2 h / Heating
3: borane-pyridine complex, 12.5percent HCl; 2.) aq. NaOH / 1.) methanol, ice-water bath, 25 min, then 4h, then 20-30 min; 2.) 1h
With
hydrogenchloride; sodium hydroxide; borane pyridine; hydrogen;
palladium on activated charcoal;
In
1,4-dioxane; water; ethyl acetate;
DOI:10.1016/S0040-4020(01)98949-5
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 87.6 percent / NaOH / dioxane; H2O / 2 h / Heating
2: borane-pyridine complex, 12.5percent HCl; 2.) aq. NaOH / 1.) methanol, ice-water bath, 25 min, then 4h, then 20-30 min; 2.) 1h
With
hydrogenchloride; sodium hydroxide; borane pyridine;
In
1,4-dioxane; water;
DOI:10.1016/S0040-4020(01)98949-5
