1-Phenyl-2-((2S,4S,6S)-6-phenyl-4-triethylsilanyloxy-tetrahydro-pyran-2-yl)-ethanol

Base Information

Chemical Name:1-Phenyl-2-((2S,4S,6S)-6-phenyl-4-triethylsilanyloxy-tetrahydro-pyran-2-yl)-ethanol
CAS No.:913723-05-4
Molecular Formula:C₂₅H₃₆O₃Si
Molecular Weight:412.645
Hs Code.:

Synonyms:1-Phenyl-2-((2S,4S,6S)-6-phenyl-4-triethylsilanyloxy-tetrahydro-pyran-2-yl)-ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Phenyl-2-((2S,4S,6S)-6-phenyl-4-triethylsilanyloxy-tetrahydro-pyran-2-yl)-ethanol

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Technology Process of 1-Phenyl-2-((2S,4S,6S)-6-phenyl-4-triethylsilanyloxy-tetrahydro-pyran-2-yl)-ethanol

There total 10 articles about 1-Phenyl-2-((2S,4S,6S)-6-phenyl-4-triethylsilanyloxy-tetrahydro-pyran-2-yl)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 913723-07-6
[(2R,4S,6S)-6-phenyl-4-triethylsilanyloxy-tetrahydro-pyran-2-yl]acetaldehyde

: phenylmagnesium bromide

: 913723-05-4
1-Phenyl-2-((2S,4S,6S)-6-phenyl-4-triethylsilanyloxy-tetrahydro-pyran-2-yl)-ethanol

Guidance literature:: In diethyl ether; at -78 - 20 ℃; for 5h;
DOI:10.1021/jo061296f

Reference yield:

: 77118-87-7,936-58-3
(S)-1-Phenyl-3-buten-1-ol

: 913723-05-4
1-Phenyl-2-((2S,4S,6S)-6-phenyl-4-triethylsilanyloxy-tetrahydro-pyran-2-yl)-ethanol

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / CH₂Cl₂ / 0 °C

2: OsO₄; NaIO₄ / dioxane; H₂O / 5 h / 20 °C

3: SmI₂ / CH₂Cl₂ / 2 h / 0 °C

4: diethyl ether; tetrahydrofuran / 2 h / -78 °C

5: 66 percent / TFA / CH₂Cl₂ / -78 - -40 °C

6: 95 percent / ozone; PPh₃ / CH₂Cl₂ / -78 - 20 °C

7: 95 percent / diethyl ether / 5 h / -78 - 20 °C

With pyridine; sodium periodate; osmium(VIII) oxide; samarium diiodide; ozone; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; 7: Grignard reaction;
DOI:10.1021/jo061296f

Reference yield:

: 913723-02-1
Acrylic acid (S)-1-phenyl-but-3-enyl ester

: 913723-05-4
1-Phenyl-2-((2S,4S,6S)-6-phenyl-4-triethylsilanyloxy-tetrahydro-pyran-2-yl)-ethanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: Grubbs' second generation catalyst / CH₂Cl₂ / 3 h / 50 °C

2.1: H₂O₂; NaOH / methanol; H₂O / 0 - 20 °C

2.2: PPTS / benzene / 0.5 h / 80 °C

3.1: (PhSe)2; NaBH₄; acetic acid / tetrahydrofuran; ethanol / 1.5 h / 0 °C

4.1: diethyl ether; tetrahydrofuran / 2 h / -78 °C

5.1: 66 percent / TFA / CH₂Cl₂ / -78 - -40 °C

6.1: 95 percent / ozone; PPh₃ / CH₂Cl₂ / -78 - 20 °C

7.1: 95 percent / diethyl ether / 5 h / -78 - 20 °C

With sodium hydroxide; sodium tetrahydroborate; diphenyl diselenide; dihydrogen peroxide; ozone; acetic acid; triphenylphosphine; trifluoroacetic acid; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; 7.1: Grignard reaction;
DOI:10.1021/jo061296f