(3S)-Dihydro-3-[(tetrahydro-2H-pyran-2-yl)oxy]-2(3H)-furanone

Base Information

• Chemical Name: (3S)-Dihydro-3-[(tetrahydro-2H-pyran-2-yl)oxy]-2(3H)-furanone
• CAS No.: 83680-34-6
• Molecular Formula: C9H14 O4
• Molecular Weight: 186.208
• Mol file: 83680-34-6.mol

Synonyms:(3S)-Dihydro-3-[(tetrahydro-2H-pyran-2-yl)oxy]-2(3H)-furanone;3-[(Tetrahydro-2H-pyran-2-yl)oxy]-2(3H)-dihydrofuranone

Chemical Property of (3S)-Dihydro-3-[(tetrahydro-2H-pyran-2-yl)oxy]-2(3H)-furanone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.483
• Boiling Point: 345.132°C at 760 mmHg
• Flash Point: 155.513°C
• Density: 1.184g/cm³
• Solubility.: Chloroform, Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

(3S)-Dihydro-3-[(tetrahydro-2H-pyran-2-yl)oxy]-2(3H)-furanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (3S)-Dihydro-3-[(tetrahydro-2H-pyran-2-yl)oxy]-2(3H)-furanone (cas# 83680-34-6) is a compound useful in organic synthesis.

Technology Process of (3S)-Dihydro-3-[(tetrahydro-2H-pyran-2-yl)oxy]-2(3H)-furanone

There total 3 articles about (3S)-Dihydro-3-[(tetrahydro-2H-pyran-2-yl)oxy]-2(3H)-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) + (3S)-3-hydroxydihydrofuran-2(3H)-one (52079-23-9) → 3-(Tetrahydro-pyran-2-yloxy)-dihydro-furan-2-one (56881-91-5,77856-34-9,77856-35-0,83680-34-6) + (S)-3-(Tetrahydro-pyran-2-yloxy)-dihydro-furan-2-one (56881-91-5,77856-34-9,77856-35-0,83680-34-6)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1021/ja00399a046

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) + (3S)-3-hydroxydihydrofuran-2(3H)-one (52079-23-9) → 3-(Tetrahydro-pyran-2-yloxy)-dihydro-furan-2-one (56881-91-5,77856-34-9,77856-35-0,83680-34-6) + (S)-3-(Tetrahydro-pyran-2-yloxy)-dihydro-furan-2-one (56881-91-5,77856-34-9,77856-35-0,83680-34-6)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1021/ja00399a046

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) + (3S)-3-hydroxydihydrofuran-2(3H)-one (52079-23-9) → (3S)-3-(Tetrahydroxy-2H-2-pyranyloxy)tetrahydro-2-furanone (83680-34-6)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane;

DOI:10.1016/S0040-4039(99)02135-8

upstream raw materials:

3,4-dihydro-2H-pyran

(3S)-3-hydroxydihydrofuran-2(3H)-one

Downstream raw materials:

(S)-1-{(S)-3-Benzyloxycarbonyl-3-[(S)-3-benzyloxycarbonyl-3-(tetrahydro-pyran-2-yloxy)-propylamino]-propyl}-azetidine-2-carboxylic acid

(S)-2-{[(S)-3-Benzyloxycarbonyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-tert-butoxycarbonyl-amino}-4-oxo-butyric acid benzyl ester

(S)-2-{[(S)-3-Benzyloxycarbonyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-tert-butoxycarbonyl-amino}-4-hydroxy-butyric acid benzyl ester

(S)-4-[tert-Butoxycarbonyl-((S)-2-oxo-tetrahydro-furan-3-yl)-amino]-2-(tetrahydro-pyran-2-yloxy)-butyric acid benzyl ester