1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluorophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methylester

Base Information

Chemical Name:1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluorophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methylester
CAS No.:170750-38-6
Molecular Formula:C₂₇H₃₀FNO₇
Molecular Weight:499.536
Hs Code.:

Synonyms:1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluorophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methylester

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Chemical Property of 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluorophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methylester

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Technology Process of 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluorophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methylester

There total 5 articles about 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluorophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 170750-37-5
1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluoprophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methyl-5-benzylester

: 170750-38-6
1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluorophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methylester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 2h; Ambient temperature;
DOI:10.1248/cpb.43.818

Reference yield:

: 1129-78-8
1-(3-bromopropoxy)-4-fluorobenzene

: 170750-38-6
1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluorophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methylester

Guidance literature:: Multi-step reaction with 2 steps

1: 29 percent / NaH / dimethylformamide / 4 h / 100 °C

2: 65 percent / H₂ / 5percent Pd/C / methanol / 2 h / Ambient temperature

With hydrogen; sodium hydride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.43.818

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 170750-38-6
1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluorophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methylester

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine, acetic acid / benzene / 2 h / Heating

2: triethylamine / benzene / 3 h / Heating

3: 29 percent / NaH / dimethylformamide / 4 h / 100 °C

4: 65 percent / H₂ / 5percent Pd/C / methanol / 2 h / Ambient temperature

With piperidine; hydrogen; sodium hydride; acetic acid; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.43.818