(R)-1-[3-(benzyloxy)benzyl]-3-[(tert-butoxycarbonyl)amino]-2-oxopyrrolidine

Base Information

Chemical Name:(R)-1-[3-(benzyloxy)benzyl]-3-[(tert-butoxycarbonyl)amino]-2-oxopyrrolidine
CAS No.:440105-51-1
Molecular Formula:C₂₃H₂₈N₂O₄
Molecular Weight:396.486
Hs Code.:

Synonyms:(R)-1-[3-(benzyloxy)benzyl]-3-[(tert-butoxycarbonyl)amino]-2-oxopyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-[3-(benzyloxy)benzyl]-3-[(tert-butoxycarbonyl)amino]-2-oxopyrrolidine

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Technology Process of (R)-1-[3-(benzyloxy)benzyl]-3-[(tert-butoxycarbonyl)amino]-2-oxopyrrolidine

There total 2 articles about (R)-1-[3-(benzyloxy)benzyl]-3-[(tert-butoxycarbonyl)amino]-2-oxopyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: (R)-2-[(tert-butoxycarbonyl)amino]-4-(dimethylsulfoniumyl)-N-[3-(benzyloxy)benzyl]butyramide iodide

: 440105-51-1
(R)-1-[3-(benzyloxy)benzyl]-3-[(tert-butoxycarbonyl)amino]-2-oxopyrrolidine

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1021/jm010531d

Reference yield:

: 440105-49-7
1-(azidomethyl)-3-(benzyloxy)benzene

: 440105-51-1
(R)-1-[3-(benzyloxy)benzyl]-3-[(tert-butoxycarbonyl)amino]-2-oxopyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

2: 98 percent / PyBOP; DIEA / CH₂Cl₂ / 18 h

3: 100 percent / 18 h

4: 96 percent / LiN(SiMe₃)2 / tetrahydrofuran / 2 h / 0 °C

With lithium aluminium tetrahydride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm010531d