3-<(3,4-dichlorophenyl)methyl>-3,6-dihydro-4,5-dimethyl-2,6-dioxo-1(2H)-pyrimidineacetic acid

Base Information

Chemical Name:3-<(3,4-dichlorophenyl)methyl>-3,6-dihydro-4,5-dimethyl-2,6-dioxo-1(2H)-pyrimidineacetic acid
CAS No.:133166-79-7
Molecular Formula:C₁₅H₁₄Cl₂N₂O₄
Molecular Weight:357.193
Hs Code.:

Synonyms:3-<(3,4-dichlorophenyl)methyl>-3,6-dihydro-4,5-dimethyl-2,6-dioxo-1(2H)-pyrimidineacetic acid

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Chemical Property of 3-<(3,4-dichlorophenyl)methyl>-3,6-dihydro-4,5-dimethyl-2,6-dioxo-1(2H)-pyrimidineacetic acid

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Technology Process of 3-<(3,4-dichlorophenyl)methyl>-3,6-dihydro-4,5-dimethyl-2,6-dioxo-1(2H)-pyrimidineacetic acid

There total 3 articles about 3-<(3,4-dichlorophenyl)methyl>-3,6-dihydro-4,5-dimethyl-2,6-dioxo-1(2H)-pyrimidineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 133167-05-2
3-<(3,4-dichlorophenyl)methyl>-3,6-dihydro-4,5-dimethyl-2,6-dioxo-1(2H)-pyrimidineacetic acid methyl ester

: 133166-79-7
3-<(3,4-dichlorophenyl)methyl>-3,6-dihydro-4,5-dimethyl-2,6-dioxo-1(2H)-pyrimidineacetic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; for 1h;
DOI:10.1021/jm00108a038

Reference yield:

: 61736-31-0
5,6-dimethyl-2H,4H-1,3-oxazine-2,4-dione

: 133166-79-7
3-<(3,4-dichlorophenyl)methyl>-3,6-dihydro-4,5-dimethyl-2,6-dioxo-1(2H)-pyrimidineacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 25.1 percent / ethanol / 1.5 h / 110 °C

2: 76.6 percent / K₂CO₃ / dimethylformamide / 4 h / 60 °C

3: 77 percent / 2.5 N aq. NaOH / methanol; tetrahydrofuran / 1 h

With sodium hydroxide; potassium carbonate; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00108a038

Reference yield:

: 133167-04-1
1-<(3,4-dichlorophenyl)methyl>-5,6-dimethyl-2,4(1H,3H)-pyrimidinedione

: 133166-79-7
3-<(3,4-dichlorophenyl)methyl>-3,6-dihydro-4,5-dimethyl-2,6-dioxo-1(2H)-pyrimidineacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 76.6 percent / K₂CO₃ / dimethylformamide / 4 h / 60 °C

2: 77 percent / 2.5 N aq. NaOH / methanol; tetrahydrofuran / 1 h

With sodium hydroxide; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00108a038