SR 1001

Base Information

Chemical Name:SR 1001
CAS No.:1335106-03-0
Molecular Formula:C₁₅H₁₃F₆N₃O₄S₂
Molecular Weight:477.408
Hs Code.:
Mol file:1335106-03-0.mol

Synonyms:N-[4-methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolyl]acetamide

Suppliers and Price of SR 1001

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
SR1001
50mg
$ 795.00

Sigma-Aldrich
SR1001 ≥98% (HPLC)
25mg
$ 501.00

Sigma-Aldrich
SR1001 ≥98% (HPLC)
5mg
$ 120.00

DC Chemicals
SR1001 >98%
100 mg
$ 600.00

Crysdot
SR1001 98+%
5mg
$ 63.00

Crysdot
SR1001 98+%
10mg
$ 105.00

Crysdot
SR1001 98+%
50mg
$ 434.00

ChemScene
SR1001 99.84%
50mg
$ 744.00

ChemScene
SR1001 99.84%
10mg
$ 180.00

ChemScene
SR1001 99.84%
5mg
$ 96.00

Total 10 raw suppliers

Chemical Property of SR 1001

Chemical Property:

PKA:5.90±0.50(Predicted)
Density:1.640±0.06 g/cm3(Predicted)
Storage Temp.:2-8°C
Solubility.:DMSO: >5mg/mL

Purity/Quality:

99%, ^*data from raw suppliers

SR1001 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22-36
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Description SR1001 (1335106-03-0) is a high affinity synthetic ligand for both RORα and RORγt acting as an inverse agonist. It binds specifically to the ligand-binding domain, inducing a conformational change which leads to diminished affinity for co-activators and increased affinity for co-repressors resulting in suppression of transcriptional activity.1?SR-1001 inhibits the development of murine TH17 cells2 and suppresses the expression of cytokines1. Suppresses insulitis and prevents hyperglycemia in a type 1 diabetes mouse model.3 Protects against pathologic neovascularization in various mouse models of retinopathy.4?Active in vivo
Uses SR 1001 is a selective RORc inverse agonist.

Technology Process of SR 1001

There total 2 articles about SR 1001 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 722-92-9
2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 69812-29-9
2-acetamido-4-methyl-5-thiazolesulfonyl chloride

: 1335106-03-0
N-[4-methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolyl]acetamide

Guidance literature:: With 2,6-dimethylpyridine; In acetone; at 60 ℃; for 18h; Inert atmosphere;

Reference yield:

: 62-53-3
aniline

: 1335106-03-0
N-[4-methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 130 °C / Neat (no solvent)

2: 2,6-dimethylpyridine / acetone / 18 h / 60 °C / Inert atmosphere

With 2,6-dimethylpyridine; toluene-4-sulfonic acid; In acetone;