3-[3-(3-(4-chlorophenyl)-1-([4-(1,1-dimethylethyl)phenyl]methyl)-1H-pyrazol-5-yl)-1,2,4-oxadiazol-5-yl]-1,2-benzenediol

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Chemical Name:3-[3-(3-(4-chlorophenyl)-1-([4-(1,1-dimethylethyl)phenyl]methyl)-1H-pyrazol-5-yl)-1,2,4-oxadiazol-5-yl]-1,2-benzenediol
CAS No.:1369695-22-6
Molecular Formula:C₂₈H₂₅ClN₄O₃
Molecular Weight:500.985
Hs Code.:

Synonyms:3-[3-(3-(4-chlorophenyl)-1-([4-(1,1-dimethylethyl)phenyl]methyl)-1H-pyrazol-5-yl)-1,2,4-oxadiazol-5-yl]-1,2-benzenediol

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Chemical Property of 3-[3-(3-(4-chlorophenyl)-1-([4-(1,1-dimethylethyl)phenyl]methyl)-1H-pyrazol-5-yl)-1,2,4-oxadiazol-5-yl]-1,2-benzenediol

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Technology Process of 3-[3-(3-(4-chlorophenyl)-1-([4-(1,1-dimethylethyl)phenyl]methyl)-1H-pyrazol-5-yl)-1,2,4-oxadiazol-5-yl]-1,2-benzenediol

There total 3 articles about 3-[3-(3-(4-chlorophenyl)-1-([4-(1,1-dimethylethyl)phenyl]methyl)-1H-pyrazol-5-yl)-1,2,4-oxadiazol-5-yl]-1,2-benzenediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 303-38-8
2,3-Dihydroxybenzoic acid

: 1369695-20-4
3-(4-chlorophenyl)-1-([4-(1,1-dimethylethyl)phenyl]methyl)-N-hydroxy-1H-pyrazole-5-carboximidamide

: 1369695-22-6
3-[3-(3-(4-chlorophenyl)-1-([4-(1,1-dimethylethyl)phenyl]methyl)-1H-pyrazol-5-yl)-1,2,4-oxadiazol-5-yl]-1,2-benzenediol

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In acetonitrile; at 120 ℃; for 4h;
DOI:10.1016/j.bmc.2012.01.032

Reference yield:

: 1369695-21-5
C₂₈H₂₇ClN₄O₄

: 1369695-22-6
3-[3-(3-(4-chlorophenyl)-1-([4-(1,1-dimethylethyl)phenyl]methyl)-1H-pyrazol-5-yl)-1,2,4-oxadiazol-5-yl]-1,2-benzenediol

Guidance literature:: With dmap; 2,3-Dihydroxybenzoic acid; dicyclohexyl-carbodiimide; In acetonitrile; at 50 ℃; for 24h;
DOI:10.1016/j.bmc.2012.01.032

Reference yield:

: 1369695-26-0
3-(4-chlorophenyl)-1-([4-(1,1-dimethylethyl)phenyl]methyl)-1H-pyrazole-5-carbonitrile

: 1369695-22-6
3-[3-(3-(4-chlorophenyl)-1-([4-(1,1-dimethylethyl)phenyl]methyl)-1H-pyrazol-5-yl)-1,2,4-oxadiazol-5-yl]-1,2-benzenediol

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; triethylamine / ethanol / 0.5 h / 80 °C / Microwave irradiation

2: dmap; dicyclohexyl-carbodiimide / acetonitrile / 4 h / 120 °C

With dmap; hydroxylamine hydrochloride; triethylamine; dicyclohexyl-carbodiimide; In ethanol; acetonitrile;
DOI:10.1016/j.bmc.2012.01.032