25-oxo-25-phosphavitamin D₃

Base Information

Chemical Name:25-oxo-25-phosphavitamin D₃
CAS No.:122778-14-7
Molecular Formula:C₂₆H₄₃O₂P
Molecular Weight:418.6
Hs Code.:

Synonyms:25-oxo-25-phosphavitamin D₃

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Chemical Property of 25-oxo-25-phosphavitamin D₃

Chemical Property:

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Technology Process of 25-oxo-25-phosphavitamin D₃

There total 14 articles about 25-oxo-25-phosphavitamin D₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: tert-Butyl-{(S)-3-[2-[(1R,3aS,7aR)-1-[(R)-4-(dimethyl-phosphinoyl)-1-methyl-butyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexyloxy}-dimethyl-silane

: 122778-14-7
25-oxo-25-phosphavitamin D₃

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/S0040-4039(01)80280-X

Reference yield:

: 55812-82-3,63730-57-4,63730-58-5,102281-42-5
(1R,3aR,4S,7aR)-7a-methyl-1-<(2E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl>-octahydro-1H-inden-4-ol

: 122778-14-7
25-oxo-25-phosphavitamin D₃

Guidance literature:: Multi-step reaction with 14 steps

1: 93 percent / imidazole / dimethylformamide

2: 1) O₃, 2) Me₂S / CH₂Cl₂ / 1) -78 deg C, 2) -78 deg C to room temp.

3: oxalic acid, SiO₂ / CH₂Cl₂

4: 72 percent / NaH / tetrahydrofuran

5: 85 percent / Li, NH₃, EtOH

6: 99 percent / TEA / CH₂Cl₂

7: NaI / acetone

8: NaCl / acetone

9: 92 percent / tetrahydrofuran / -78 °C

10: H₂O₂

11: 99 percent / tetra-n-butylammonium fluoride / CH₂Cl₂ / Heating

12: 90 percent / oxalyl chloride, DMSO, TEA / CH₂Cl₂

13: 56 percent / butyl lithium / tetrahydrofuran / -78 °C

14: 76 percent / tetrabutylammonium fluoride / tetrahydrofuran

With 1H-imidazole; n-butyllithium; oxalyl dichloride; dimethylsulfide; ethanol; TEA; tetrabutyl ammonium fluoride; ammonia; dihydrogen peroxide; oxalic acid; silica gel; lithium; sodium hydride; ozone; dimethyl sulfoxide; sodium iodide; sodium chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4039(01)80280-X

Reference yield:

: 100928-02-7
(24R,22E)-de-A,B-8β-<(tert-butyldimethylsilyl)oxy>ergost-22-ene

: 122778-14-7
25-oxo-25-phosphavitamin D₃

Guidance literature:: Multi-step reaction with 13 steps

1: 1) O₃, 2) Me₂S / CH₂Cl₂ / 1) -78 deg C, 2) -78 deg C to room temp.

2: oxalic acid, SiO₂ / CH₂Cl₂

3: 72 percent / NaH / tetrahydrofuran

4: 85 percent / Li, NH₃, EtOH

5: 99 percent / TEA / CH₂Cl₂

6: NaI / acetone

7: NaCl / acetone

8: 92 percent / tetrahydrofuran / -78 °C

9: H₂O₂

10: 99 percent / tetra-n-butylammonium fluoride / CH₂Cl₂ / Heating

11: 90 percent / oxalyl chloride, DMSO, TEA / CH₂Cl₂

12: 56 percent / butyl lithium / tetrahydrofuran / -78 °C

13: 76 percent / tetrabutylammonium fluoride / tetrahydrofuran

With n-butyllithium; oxalyl dichloride; dimethylsulfide; ethanol; TEA; tetrabutyl ammonium fluoride; ammonia; dihydrogen peroxide; oxalic acid; silica gel; lithium; sodium hydride; ozone; dimethyl sulfoxide; sodium iodide; sodium chloride; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1016/S0040-4039(01)80280-X