methanesulphonic acid 3-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexylcarbamoyl]-5-((R)-1-phenyl-ethylcarbamoyl)-phenyl ester

Base Information

Chemical Name:methanesulphonic acid 3-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexylcarbamoyl]-5-((R)-1-phenyl-ethylcarbamoyl)-phenyl ester
CAS No.:1067648-25-2
Molecular Formula:C₄₅H₅₆N₄O₉S
Molecular Weight:829.027
Hs Code.:

methanesulphonic acid 3-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexylcarbamoyl]-5-((R)-1-phenyl-ethylcarbamoyl)-phenyl ester

Synonyms:methanesulphonic acid 3-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexylcarbamoyl]-5-((R)-1-phenyl-ethylcarbamoyl)-phenyl ester

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Chemical Property of methanesulphonic acid 3-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexylcarbamoyl]-5-((R)-1-phenyl-ethylcarbamoyl)-phenyl ester

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Technology Process of methanesulphonic acid 3-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexylcarbamoyl]-5-((R)-1-phenyl-ethylcarbamoyl)-phenyl ester

There total 15 articles about methanesulphonic acid 3-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexylcarbamoyl]-5-((R)-1-phenyl-ethylcarbamoyl)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1067648-76-3
(R)-3-(methylsulfonyloxy)-5-(1-phenylethylcarbamoyl)benzoic acid

: 1056670-82-6
(2S,4S,5S)-5-amino-6-benzyloxy-4-hydroxy-2-isopropyl-hexanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)amide

: 1067648-25-2
methanesulphonic acid 3-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexylcarbamoyl]-5-((R)-1-phenyl-ethylcarbamoyl)-phenyl ester

Guidance literature:: (R)-3-(methylsulfonyloxy)-5-(1-phenylethylcarbamoyl)benzoic acid; With diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.0333333h;

(2S,4S,5S)-5-amino-6-benzyloxy-4-hydroxy-2-isopropyl-hexanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)amide; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

Reference yield:

: 1056674-45-3
(3S,5S)-5-((R)-1,2-dihydroxyethyl)-3-isopropyldihydrofuran-2(3H)-one

: 1067648-25-2
methanesulphonic acid 3-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexylcarbamoyl]-5-((R)-1-phenyl-ethylcarbamoyl)-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: di(n-butyl)tin oxide / toluene / 4 h / Heating / reflux

1.2: 22 h / 90 °C

2.1: pyridine; trifluoromethylsulfonic anhydride / dichloromethane / 0.5 - 1 h / 0 - 20 °C

2.2: 1 h / 60 - 70 °C

3.1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 72 - 88 h / 70 °C

4.1: hydrogen / 5 % Pd/CaCO3 / ethanol / 5 h / 760.05 Torr

5.1: diisopropylamine; HATU / N,N-dimethyl-formamide / 0.03 h / 20 °C

5.2: 0.08 h / 20 °C

With pyridine; 2-hydroxypyridin; trifluoromethylsulfonic anhydride; hydrogen; di(n-butyl)tin oxide; diisopropylamine; N-ethyl-N,N-diisopropylamine; HATU; 5 % Pd/CaCO3; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1056674-54-4
(3S,5S)-5-[(1R)-2-(benzyloxy)-1-hydroxyethyl]-3-isopropyldihydrofuran-2(3H)-one

: 1067648-25-2
methanesulphonic acid 3-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexylcarbamoyl]-5-((R)-1-phenyl-ethylcarbamoyl)-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; trifluoromethylsulfonic anhydride / dichloromethane / 0.5 - 1 h / 0 - 20 °C

1.2: 1 h / 60 - 70 °C

2.1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 72 - 88 h / 70 °C

3.1: hydrogen / 5 % Pd/CaCO3 / ethanol / 5 h / 760.05 Torr

4.1: diisopropylamine; HATU / N,N-dimethyl-formamide / 0.03 h / 20 °C

4.2: 0.08 h / 20 °C

With pyridine; 2-hydroxypyridin; trifluoromethylsulfonic anhydride; hydrogen; diisopropylamine; N-ethyl-N,N-diisopropylamine; HATU; 5 % Pd/CaCO3; In ethanol; dichloromethane; N,N-dimethyl-formamide;