(4S,4aS,5aR,12aS)-4-dimethylamino-7-[3-(2-dimethylamino-acetylamino)-phenyl]-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide

Base Information

Chemical Name:(4S,4aS,5aR,12aS)-4-dimethylamino-7-[3-(2-dimethylamino-acetylamino)-phenyl]-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide
CAS No.:1035976-22-7
Molecular Formula:C₃₁H₃₄N₄O₈
Molecular Weight:590.633
Hs Code.:

(4S,4aS,5aR,12aS)-4-dimethylamino-7-[3-(2-dimethylamino-acetylamino)-phenyl]-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide

Synonyms:(4S,4aS,5aR,12aS)-4-dimethylamino-7-[3-(2-dimethylamino-acetylamino)-phenyl]-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide

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Chemical Property of (4S,4aS,5aR,12aS)-4-dimethylamino-7-[3-(2-dimethylamino-acetylamino)-phenyl]-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide

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Technology Process of (4S,4aS,5aR,12aS)-4-dimethylamino-7-[3-(2-dimethylamino-acetylamino)-phenyl]-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide

There total 5 articles about (4S,4aS,5aR,12aS)-4-dimethylamino-7-[3-(2-dimethylamino-acetylamino)-phenyl]-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1035978-64-3
7-(3-amino-phenyl)-sancycline trifluoroacetic acid salt

: 51552-16-0
dimethylaminoacetyl chloride

: 1035976-22-7
(4S,4aS,5aR,12aS)-4-dimethylamino-7-[3-(2-dimethylamino-acetylamino)-phenyl]-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide

: (4R,4aS,5aR,12aS)-4-dimethylamino-7-[3-(2-dimethylamino-acetylamino)-phenyl]-3,10,12,12a-tetrahydroxy-1,11-dioxo-1a4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; at 100 ℃; for 0.0833333h; Inert atmosphere; Sealed tube;

Reference yield:

: 30418-59-8,280563-63-5
3-Aminophenylboronic acid

: 1035976-22-7
(4S,4aS,5aR,12aS)-4-dimethylamino-7-[3-(2-dimethylamino-acetylamino)-phenyl]-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium acetate / palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ISOPROPYLAMIDE; water / 0.5 h / 120 °C / Microwave irradiation

2: N-ethyl-N,N-diisopropylamine / 0.17 h / 100 °C

With sodium acetate; N-ethyl-N,N-diisopropylamine; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ISOPROPYLAMIDE; water; 1: Suzuki Coupling;

Reference yield:

: [4S-(4α,12aα)]-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-7-iodo-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydronaphthacene-2-carboxamide trifluoroacetate

: 1035976-22-7
(4S,4aS,5aR,12aS)-4-dimethylamino-7-[3-(2-dimethylamino-acetylamino)-phenyl]-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium acetate / palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ISOPROPYLAMIDE; water / 0.5 h / 120 °C / Microwave irradiation

2: N-ethyl-N,N-diisopropylamine / 0.17 h / 100 °C

With sodium acetate; N-ethyl-N,N-diisopropylamine; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ISOPROPYLAMIDE; water; 1: Suzuki Coupling;