1-[2-(4-bromophenyl)-2-oxoethyl]-1H-benzimidazole-5-carbonitrile

Base Information

• Chemical Name: 1-[2-(4-bromophenyl)-2-oxoethyl]-1H-benzimidazole-5-carbonitrile
• CAS No.: 202124-51-4
• Molecular Formula: C₁₆H₁₀BrN₃O
• Molecular Weight: 340.179
• Mol file: 202124-51-4.mol

Synonyms:1-[2-(4-bromophenyl)-2-oxoethyl]-1H-benzimidazole-5-carbonitrile

Chemical Property of 1-[2-(4-bromophenyl)-2-oxoethyl]-1H-benzimidazole-5-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-[2-(4-bromophenyl)-2-oxoethyl]-1H-benzimidazole-5-carbonitrile

There total 2 articles about 1-[2-(4-bromophenyl)-2-oxoethyl]-1H-benzimidazole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

para-bromophenacyl bromide (99-73-0,132309-76-3) + 1H-benzo[d]imidazole-6-carbonitrile (6287-83-8) → 1-[2-(4-bromophenyl)-2-oxoethyl]-1H-benzimidazole-5-carbonitrile (202124-51-4) + 1-[2-(4-bromophenyl)-2-oxoethyl]-1H-benzimidazole-6-carbonitrile (202124-50-3)

Guidance literature:

1H-benzo[d]imidazole-6-carbonitrile; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;

para-bromophenacyl bromide; In tetrahydrofuran; for 2h; Further stages.; Heating;

DOI:10.1021/jm000113t

Reference yield:

→ 1-[2-(4-bromophenyl)-2-oxoethyl]-1H-benzimidazole-5-carbonitrile (202124-51-4)

Guidance literature:

Reference yield:

1-[2-(4-bromophenyl)-2-oxoethyl]-1H-benzimidazole-5-carbonitrile (202124-51-4) → [4-(phenyl)phenylcarbonyl]methyl-5-amidinobenzimidazole

Guidance literature:

Multi-step reaction with 2 steps

1.1: Pd(PPh₃)4; aq. Na₂CO₃ / tetrahydrofuran / 16 h / Heating

2.1: HCl(g); EtOH / 16 h / 20 °C

2.2: (NH₄)2CO₃ / ethanol / 24 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; sodium carbonate; In tetrahydrofuran; 1.1: Suzuki coupling;

DOI:10.1021/jm000113t

upstream raw materials:

para-bromophenacyl bromide

1H-benzo[d]imidazole-6-carbonitrile