2-[5-(2'-tert-butylaminosulfonyl)phenyl-oxoisoindolin-2-yl]-2-phenylacetic acid

Base Information

• Chemical Name: 2-[5-(2'-tert-butylaminosulfonyl)phenyl-oxoisoindolin-2-yl]-2-phenylacetic acid
• CAS No.: 477716-94-2
• Molecular Formula: C₂₆H₂₆N₂O₅S
• Molecular Weight: 478.569

Synonyms:2-[5-(2'-tert-butylaminosulfonyl)phenyl-oxoisoindolin-2-yl]-2-phenylacetic acid

Chemical Property of 2-[5-(2'-tert-butylaminosulfonyl)phenyl-oxoisoindolin-2-yl]-2-phenylacetic acid

Chemical Property:

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Technology Process of 2-[5-(2'-tert-butylaminosulfonyl)phenyl-oxoisoindolin-2-yl]-2-phenylacetic acid

There total 1 articles about 2-[5-(2'-tert-butylaminosulfonyl)phenyl-oxoisoindolin-2-yl]-2-phenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 2-[5-(2'-tert-butylaminosulfonyl)phenyl-oxoisoindolin-2-yl]-2-phenylacetate (477716-93-1) → 2-[5-(2'-tert-butylaminosulfonyl)phenyl-oxoisoindolin-2-yl]-2-phenylacetic acid (477716-94-2)

Guidance literature:

With LiOH; In tetrahydrofuran;

Reference yield: 84.0%

3-amino-4-(benzyloxy)benzonitrile (220799-40-6) + 2-[5-(2'-tert-butylaminosulfonyl)phenyl-oxoisoindolin-2-yl]-2-phenylacetic acid (477716-94-2) → 2-[5-(2'-tert-butylaminosulfonyl)phenyl-oxoisoindolin-2-yl]-N-(2-benzoxy-5-cyano-phenyl)-2-phenylacetamide (477716-96-4)

Guidance literature:

With triethanolamine; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield: 78.0%

35-amino-2-fluorobenzonitrile + 2-[5-(2'-tert-butylaminosulfonyl)phenyl-oxoisoindolin-2-yl]-2-phenylacetic acid (477716-94-2) → 2-[5-(2'-tert-butylaminosulfonyl)phenyl-oxoisoindolin-2-yl]-N-(3-cyano-4-fluorophenyl)-2-phenylacetamide (477716-99-7)

Guidance literature:

With triethanolamine; In ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

methyl 2-[5-(2'-tert-butylaminosulfonyl)phenyl-oxoisoindolin-2-yl]-2-phenylacetate

Downstream raw materials:

2-[5-(2'-tert-butylaminosulfonyl)phenyl-oxoisoindolin-2-yl]-N-(3-cyanophenyl)-2-phenylacetamide

2-[5-(2'-tert-butylaminosulfonyl)phenyl-oxoisoindolin-2-yl]-N-(2-benzoxy-5-cyano-phenyl)-2-phenylacetamide

2-[5-(2'-tert-butylaminosulfonyl)phenyl-oxoisoindolin-2-yl]-N-(3-cyano-4-fluorophenyl)-2-phenylacetamide

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