(4R)-5-(benzyloxy)-4-methylpentanal

Base Information

Chemical Name:(4R)-5-(benzyloxy)-4-methylpentanal
CAS No.:1267597-10-3
Molecular Formula:C₁₃H₁₈O₂
Molecular Weight:206.285
Hs Code.:

Synonyms:(4R)-5-(benzyloxy)-4-methylpentanal

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Chemical Property of (4R)-5-(benzyloxy)-4-methylpentanal

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Technology Process of (4R)-5-(benzyloxy)-4-methylpentanal

There total 13 articles about (4R)-5-(benzyloxy)-4-methylpentanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1267597-08-9
(4R)-5-(benzyloxy)-4-methylpentan-1-ol

: 1267597-10-3
(4R)-5-(benzyloxy)-4-methylpentanal

Guidance literature:: (4R)-5-(benzyloxy)-4-methylpentan-1-ol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -90 ℃; for 0.5h; Inert atmosphere;

With triethylamine; In dichloromethane; at -90 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1002/chem.201001752

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 1267597-10-3
(4R)-5-(benzyloxy)-4-methylpentanal

Guidance literature:: Multi-step reaction with 6 steps

1.1: dihydrogen peroxide / methanol; water / 0.5 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 2.5 h / 0 - 20 °C / Inert atmosphere

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 - 20 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 °C / Inert atmosphere

5.1: sodium hydride / 1,2-dimethoxyethane; mineral oil / 0.17 h / 20 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere; Reflux

6.1: ozone / dichloromethane / 0.75 h / -78 °C

6.2: 19 h / -78 - 20 °C

With lithium aluminium tetrahydride; n-butyllithium; dihydrogen peroxide; sodium hexamethyldisilazane; sodium hydride; ozone; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; hexane; dichloromethane; water; mineral oil;
DOI:10.1039/c5ob02023a

Reference yield:

: (4R)-3-(hex-5-enoyl)-5,5-dimethyl-4-(propan-2-yl)-1,3-oxazolidin-2-one

: 1267597-10-3
(4R)-5-(benzyloxy)-4-methylpentanal

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 - 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 °C / Inert atmosphere

3.1: sodium hydride / 1,2-dimethoxyethane; mineral oil / 0.17 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere; Reflux

4.1: ozone / dichloromethane / 0.75 h / -78 °C

4.2: 19 h / -78 - 20 °C

With lithium aluminium tetrahydride; sodium hexamethyldisilazane; sodium hydride; ozone; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; mineral oil;
DOI:10.1039/c5ob02023a