5-[8-(tert-butyldiphenylsilyloxy)-(3S,7R)-3,7-dimethyloctanesulfonyl]-1-phenyl-1H-tetrazole

Base Information

Chemical Name:5-[8-(tert-butyldiphenylsilyloxy)-(3S,7R)-3,7-dimethyloctanesulfonyl]-1-phenyl-1H-tetrazole
CAS No.:1443233-27-9
Molecular Formula:C₃₃H₄₄N₄O₃SSi
Molecular Weight:604.889
Hs Code.:

Synonyms:5-[8-(tert-butyldiphenylsilyloxy)-(3S,7R)-3,7-dimethyloctanesulfonyl]-1-phenyl-1H-tetrazole

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Chemical Property of 5-[8-(tert-butyldiphenylsilyloxy)-(3S,7R)-3,7-dimethyloctanesulfonyl]-1-phenyl-1H-tetrazole

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Technology Process of 5-[8-(tert-butyldiphenylsilyloxy)-(3S,7R)-3,7-dimethyloctanesulfonyl]-1-phenyl-1H-tetrazole

There total 4 articles about 5-[8-(tert-butyldiphenylsilyloxy)-(3S,7R)-3,7-dimethyloctanesulfonyl]-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1443233-26-8
5-[8-(tert-butyldiphenylsilyloxy)-(3S,7R)-3,7-dimethyloctylsulfanyl]-1-phenyl-1H-tetrazole

: 1443233-27-9
5-[8-(tert-butyldiphenylsilyloxy)-(3S,7R)-3,7-dimethyloctanesulfonyl]-1-phenyl-1H-tetrazole

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jo4006602

Reference yield:

: 8-benzoxy-1-(tert-butyldiphenylsilyloxy)-(2R,6R)-2,6-dimethyl-4-(Z/E)-4-octene

: 1443233-27-9
5-[8-(tert-butyldiphenylsilyloxy)-(3S,7R)-3,7-dimethyloctanesulfonyl]-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine; copper(II) sulfate; oxygen / ethanol / 15 h / 70 °C

2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 20 °C

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; oxygen; copper(II) sulfate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; hydrazine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo4006602

Reference yield:

: 1443233-18-8
8-(tert-butyldiphenylsilyloxy)-(3S,7R)-3,7-dimethyl-1-octanol

: 1443233-27-9
5-[8-(tert-butyldiphenylsilyloxy)-(3S,7R)-3,7-dimethyloctanesulfonyl]-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

With 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo4006602