(2R,3R,5R)-2-benzyl-3-(tert-butyldimethylsilyloxy)-1-methyl-5-phenylpyrrolidine

Base Information

Chemical Name:(2R,3R,5R)-2-benzyl-3-(tert-butyldimethylsilyloxy)-1-methyl-5-phenylpyrrolidine
CAS No.:1616379-88-4
Molecular Formula:C₂₄H₃₅NOSi
Molecular Weight:381.634
Hs Code.:

Synonyms:(2R,3R,5R)-2-benzyl-3-(tert-butyldimethylsilyloxy)-1-methyl-5-phenylpyrrolidine

Suppliers and Price of (2R,3R,5R)-2-benzyl-3-(tert-butyldimethylsilyloxy)-1-methyl-5-phenylpyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3R,5R)-2-benzyl-3-(tert-butyldimethylsilyloxy)-1-methyl-5-phenylpyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3R,5R)-2-benzyl-3-(tert-butyldimethylsilyloxy)-1-methyl-5-phenylpyrrolidine

There total 11 articles about (2R,3R,5R)-2-benzyl-3-(tert-butyldimethylsilyloxy)-1-methyl-5-phenylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: C₂₃H₃₃NOSi

: 1616379-88-4
(2R,3R,5R)-2-benzyl-3-(tert-butyldimethylsilyloxy)-1-methyl-5-phenylpyrrolidine

Guidance literature:: In methanol; for 3h;
DOI:10.1016/j.tet.2014.05.037

Reference yield:

: 1616379-97-5
(R)-N-((1S,3R)-3,4-bis(tert-butyldimethylsilyloxy)-1-phenylbutyl)-2-methylpropane-2-sulfinamide

: 1616379-88-4
(2R,3R,5R)-2-benzyl-3-(tert-butyldimethylsilyloxy)-1-methyl-5-phenylpyrrolidine

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogenchloride / ethanol; 1,4-dioxane / 0.5 h / 0 °C

2: triethylamine / dichloromethane

3: sarett reagent / N,N-dimethyl-formamide / 24 h / 20 °C

4: diethyl ether / 3 h / -78 - 20 °C

5: trifluoroacetic acid / 1 h / 20 °C

6: sodium hydroxide / water / pH 10 - 12

7: palladium 10% on activated carbon; hydrogen; 20% palladium hydroxide-activated charcoal / methanol / 8 h

8: methanol / 3 h

With hydrogenchloride; sarett reagent; palladium 10% on activated carbon; 20% palladium hydroxide-activated charcoal; hydrogen; triethylamine; trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2014.05.037

Reference yield:

: 1616379-74-8
(3R,5R)-tert-butyl 3-(tert-butyldimethylsilyloxy)-2-oxo-5-phenylpyrrolidine-1-carboxylate

: 1616379-88-4
(2R,3R,5R)-2-benzyl-3-(tert-butyldimethylsilyloxy)-1-methyl-5-phenylpyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1: diethyl ether / 3 h / -78 - 20 °C

2: trifluoroacetic acid / 1 h / 20 °C

3: sodium hydroxide / water / pH 10 - 12

4: palladium 10% on activated carbon; hydrogen; 20% palladium hydroxide-activated charcoal / methanol / 8 h

5: methanol / 3 h

With palladium 10% on activated carbon; 20% palladium hydroxide-activated charcoal; hydrogen; trifluoroacetic acid; sodium hydroxide; In methanol; diethyl ether; water;
DOI:10.1016/j.tet.2014.05.037