3-(5-((2-(4-fluorophenyl)-2-methylpropyl)amino)-1,2,4-thiadiazol-3-yl)-N,N-dimethylbenzamide

Base Information

Chemical Name:3-(5-((2-(4-fluorophenyl)-2-methylpropyl)amino)-1,2,4-thiadiazol-3-yl)-N,N-dimethylbenzamide
CAS No.:1409946-65-1
Molecular Formula:C₂₁H₂₃FN₄OS
Molecular Weight:398.504
Hs Code.:

Synonyms:3-(5-((2-(4-fluorophenyl)-2-methylpropyl)amino)-1,2,4-thiadiazol-3-yl)-N,N-dimethylbenzamide

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Chemical Property of 3-(5-((2-(4-fluorophenyl)-2-methylpropyl)amino)-1,2,4-thiadiazol-3-yl)-N,N-dimethylbenzamide

Chemical Property:

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Technology Process of 3-(5-((2-(4-fluorophenyl)-2-methylpropyl)amino)-1,2,4-thiadiazol-3-yl)-N,N-dimethylbenzamide

There total 3 articles about 3-(5-((2-(4-fluorophenyl)-2-methylpropyl)amino)-1,2,4-thiadiazol-3-yl)-N,N-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1409949-45-6
3-bromo-N-(2-(4-fluorophenyl)-2-methylpropyl)-1,2,4-thiadiazol-5-amine

: N,N-dimethylbenzamide-3-boronic acid

: 1409946-65-1
3-(5-((2-(4-fluorophenyl)-2-methylpropyl)amino)-1,2,4-thiadiazol-3-yl)-N,N-dimethylbenzamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; at 110 ℃; for 0.166667h; Microwave irradiation;
DOI:10.1021/acs.jmedchem.1c01067

Reference yield:

: 2-methyl-2-(4-fluorophenyl)propylamine

: 1409946-65-1
3-(5-((2-(4-fluorophenyl)-2-methylpropyl)amino)-1,2,4-thiadiazol-3-yl)-N,N-dimethylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 0 - 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane / 0.17 h / 110 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; dichloromethane; 2: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.1c01067