(4-(6-bromo-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)methanamine

Base Information

Chemical Name:(4-(6-bromo-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)methanamine
CAS No.:1095381-75-1
Molecular Formula:C₂₂H₂₄BrN₇O
Molecular Weight:482.383
Hs Code.:

Synonyms:(4-(6-bromo-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)methanamine

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Chemical Property of (4-(6-bromo-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)methanamine

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Technology Process of (4-(6-bromo-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)methanamine

There total 1 articles about (4-(6-bromo-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 942949-26-0
5-bromo-4-[4-[(5-methyl-isoxazol-3-yl)methyl]piperazin-1-yl]-3-nitro-pyridin-2-ylamine

: 156866-52-3
tert-butyl N-(4-formylbenzyl)carbamate

: 1095381-75-1
(4-(6-bromo-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)methanamine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium dithionite / ethanol; water / 19 h / 80 °C

2: trifluoroacetic acid / dichloromethane / 1.25 h / 20 °C

With sodium dithionite; trifluoroacetic acid; In ethanol; dichloromethane; water;

Reference yield: 6.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1095381-75-1
(4-(6-bromo-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)methanamine

: 1095381-77-3
1-(4-(6-bromo-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)-N,N-dimethylmethanamine

Guidance literature:: formaldehyd; (4-(6-bromo-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)methanamine; In tetrahydrofuran; methanol; water; at 20 ℃; for 0.0833333h;

With sodium cyanoborohydride; In tetrahydrofuran; methanol; water; at 20 ℃; for 4.5h;
DOI:10.1021/jm100262j