3-[1-(4-Methoxy-phenyl)-5-thiophen-2-yl-1H-pyrazol-3-yl]-propionic acid

Base Information

• Chemical Name: 3-[1-(4-Methoxy-phenyl)-5-thiophen-2-yl-1H-pyrazol-3-yl]-propionic acid
• CAS No.: 133390-69-9
• Molecular Formula: C₁₇H₁₆N₂O₃S
• Molecular Weight: 328.392

Synonyms:3-[1-(4-Methoxy-phenyl)-5-thiophen-2-yl-1H-pyrazol-3-yl]-propionic acid

Chemical Property of 3-[1-(4-Methoxy-phenyl)-5-thiophen-2-yl-1H-pyrazol-3-yl]-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[1-(4-Methoxy-phenyl)-5-thiophen-2-yl-1H-pyrazol-3-yl]-propionic acid

There total 2 articles about 3-[1-(4-Methoxy-phenyl)-5-thiophen-2-yl-1H-pyrazol-3-yl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-methoxyphenylhydrazine hydrochloride (19501-58-7) + 4,6-Dioxo-6-(2-thienyl)hexanoic acid (126724-39-8) → 3-[1-(4-Methoxy-phenyl)-5-thiophen-2-yl-1H-pyrazol-3-yl]-propionic acid (133390-69-9)

Guidance literature:

With triethylamine; In methanol; for 6h; Ambient temperature;

DOI:10.1055/s-1991-26367

Reference yield:

2-Acetylthiophene (88-15-3,97511-16-5) → 3-[1-(4-Methoxy-phenyl)-5-thiophen-2-yl-1H-pyrazol-3-yl]-propionic acid (133390-69-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) lithium bis(trimethylsilyl)amide / 1.) heptane, THF, -20 deg C, 30 min, 2.) -20 deg C, 1h, 3.) r.t., overnight

2: 86 percent / NEt₃ / methanol / 6 h / Ambient temperature

With triethylamine; lithium hexamethyldisilazane; In methanol;

DOI:10.1055/s-1991-26367

Reference yield:

3-[1-(4-Methoxy-phenyl)-5-thiophen-2-yl-1H-pyrazol-3-yl]-propionic acid (133390-69-9) → 3-[1-(4-Methoxy-phenyl)-5-thiophen-2-yl-1H-pyrazol-3-yl]-propionyl chloride

Guidance literature:

With oxalyl dichloride; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1055/s-1991-26367

upstream raw materials:

4-methoxyphenylhydrazine hydrochloride

4,6-Dioxo-6-(2-thienyl)hexanoic acid

2-Acetylthiophene

Downstream raw materials:

3-[1-(4-methoxyphenyl)-5-(thien-2-yl)-3-pyrazolyl]-N-hydroxy-N-methylpropanamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 133390-69-9 3-[1-(4-Methoxy-phenyl)-5-thiophen-2-yl-1H-pyrazol-3-yl]-propionic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send