(4aS,6S,8aS)-6-(tert-Butyl-diphenyl-silanyloxy)-8a-(2-trimethylsilanyl-ethoxymethoxymethyl)-octahydro-naphthalen-1-one

Base Information

Chemical Name:(4aS,6S,8aS)-6-(tert-Butyl-diphenyl-silanyloxy)-8a-(2-trimethylsilanyl-ethoxymethoxymethyl)-octahydro-naphthalen-1-one
CAS No.:1026931-54-3
Molecular Formula:C₃₃H₅₀O₄Si₂
Molecular Weight:566.929
Hs Code.:

Synonyms:(4aS,6S,8aS)-6-(tert-Butyl-diphenyl-silanyloxy)-8a-(2-trimethylsilanyl-ethoxymethoxymethyl)-octahydro-naphthalen-1-one

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Chemical Property of (4aS,6S,8aS)-6-(tert-Butyl-diphenyl-silanyloxy)-8a-(2-trimethylsilanyl-ethoxymethoxymethyl)-octahydro-naphthalen-1-one

Chemical Property:

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Technology Process of (4aS,6S,8aS)-6-(tert-Butyl-diphenyl-silanyloxy)-8a-(2-trimethylsilanyl-ethoxymethoxymethyl)-octahydro-naphthalen-1-one

There total 5 articles about (4aS,6S,8aS)-6-(tert-Butyl-diphenyl-silanyloxy)-8a-(2-trimethylsilanyl-ethoxymethoxymethyl)-octahydro-naphthalen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 615249-09-7
C₃₅H₅₄O₅Si₂

: 1026931-54-3
(4aS,6S,8aS)-6-(tert-Butyl-diphenyl-silanyloxy)-8a-(2-trimethylsilanyl-ethoxymethoxymethyl)-octahydro-naphthalen-1-one

Guidance literature:: With pyridinium p-toluenesulfonate; In acetone; at 65 ℃; for 24h;
DOI:10.1002/anie.200351744

Reference yield:

: 98770-78-6
(S)-3,4,8,8a-tetrahydro-8a-(hydroxymethyl)-1,6-(2H,7H)-naphthalenedione-1-ethylene acetal

: 1026931-54-3
(4aS,6S,8aS)-6-(tert-Butyl-diphenyl-silanyloxy)-8a-(2-trimethylsilanyl-ethoxymethoxymethyl)-octahydro-naphthalen-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / i-Pr₂NEt / CH₂Cl₂ / 20 h / 25 °C

2: 80 percent / Li; liq. NH₃ / 1 h / -78 °C

3: 99 percent / NaBH₄ / tetrahydrofuran; ethanol / 3 h / -78 - 25 °C

4: 80 percent / imidazole; DMAP / dimethylformamide / 24 h / 25 °C

5: PPTS / acetone / 24 h / 65 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; ammonia; pyridinium p-toluenesulfonate; lithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; 2: Birch reduction;
DOI:10.1002/anie.200351744

Reference yield:

: 615249-06-4
C₁₉H₃₂O₅Si

: 1026931-54-3
(4aS,6S,8aS)-6-(tert-Butyl-diphenyl-silanyloxy)-8a-(2-trimethylsilanyl-ethoxymethoxymethyl)-octahydro-naphthalen-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / Li; liq. NH₃ / 1 h / -78 °C

2: 99 percent / NaBH₄ / tetrahydrofuran; ethanol / 3 h / -78 - 25 °C

3: 80 percent / imidazole; DMAP / dimethylformamide / 24 h / 25 °C

4: PPTS / acetone / 24 h / 65 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; ammonia; pyridinium p-toluenesulfonate; lithium; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetone; 1: Birch reduction;
DOI:10.1002/anie.200351744