6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [5-(4-methoxy-phenyl)-[1,3,4]thiadiazol-2-yl]-amide

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Chemical Name:6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [5-(4-methoxy-phenyl)-[1,3,4]thiadiazol-2-yl]-amide
CAS No.:1316121-36-4
Molecular Formula:C₂₂H₁₉N₇O₂S
Molecular Weight:445.505
Hs Code.:

Synonyms:6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [5-(4-methoxy-phenyl)-[1,3,4]thiadiazol-2-yl]-amide

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Chemical Property of 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [5-(4-methoxy-phenyl)-[1,3,4]thiadiazol-2-yl]-amide

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Technology Process of 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [5-(4-methoxy-phenyl)-[1,3,4]thiadiazol-2-yl]-amide

There total 3 articles about 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [5-(4-methoxy-phenyl)-[1,3,4]thiadiazol-2-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 1014-25-1
5-(4-methoxy-phenyl)-[1,3,4]thiadiazol-2-ylamine

: 1316121-97-7
6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid ethyl ester

: 1316121-36-4
6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [5-(4-methoxy-phenyl)-[1,3,4]thiadiazol-2-yl]-amide

Guidance literature:: With trimethylaluminum; In 1,4-dioxane; n-heptane; Inert atmosphere; Reflux;

Reference yield:

: 3-Amino-6-cyclopropyl-pyridine-2-carboxylic acid ethyl ester

: 1316121-36-4
6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [5-(4-methoxy-phenyl)-[1,3,4]thiadiazol-2-yl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / o-xylene; water / 140 °C / Inert atmosphere

2: trimethylaluminum / n-heptane; 1,4-dioxane / Inert atmosphere; Reflux

With trimethylaluminum; potassium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; n-heptane; o-xylene; water;

Reference yield:

: 28033-08-1
ethyl 3-amino-6-bromo-pyridine-2-carboxylate

: 1316121-36-4
6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [5-(4-methoxy-phenyl)-[1,3,4]thiadiazol-2-yl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate / tricyclohexylphosphine; palladium diacetate / toluene; water / 24 h / 100 °C

2: potassium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / o-xylene; water / 140 °C / Inert atmosphere

3: trimethylaluminum / n-heptane; 1,4-dioxane / Inert atmosphere; Reflux

With potassium phosphate; trimethylaluminum; potassium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tricyclohexylphosphine; In 1,4-dioxane; n-heptane; o-xylene; water; toluene;