Technology Process of 4-pyridylphenyl methanethiosulfonate
There total 5 articles about 4-pyridylphenyl methanethiosulfonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-BuLi / hexane; tetrahydrofuran / 0.25 h / -78 °C
1.2: triisopropoxy borate / tetrahydrofuran; hexane / -78 - 20 °C
1.3: water / tetrahydrofuran; hexane
2.1: 63 percent / KOH; Bu4NBr / tetrakis(triphenylphosphine)palladium / 1,2-dimethoxy-ethane; H2O / 48 h / 80 °C
3.1: 81.1 percent / t-BuSNa / dimethylformamide / 5 h / Heating
4.1: 50 percent / vanadyl acetylacetonate; tert-butylhydroperoxide / CH2Cl2; decane / -15 - 20 °C
5.1: 71.4 percent / silver nitrate / acetone; H2O / 1 h / Heating
With
tert.-butylhydroperoxide; potassium hydroxide; n-butyllithium; vanadyl acetylacetonate; tetrabutylammomium bromide; sodium tert-butyl thiolate; silver nitrate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,2-dimethoxyethane; decane; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone;
2.1: Suzuki coupling;
DOI:10.1016/j.bmc.2006.09.058
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 63 percent / KOH; Bu4NBr / tetrakis(triphenylphosphine)palladium / 1,2-dimethoxy-ethane; H2O / 48 h / 80 °C
2: 81.1 percent / t-BuSNa / dimethylformamide / 5 h / Heating
3: 50 percent / vanadyl acetylacetonate; tert-butylhydroperoxide / CH2Cl2; decane / -15 - 20 °C
4: 71.4 percent / silver nitrate / acetone; H2O / 1 h / Heating
With
tert.-butylhydroperoxide; potassium hydroxide; vanadyl acetylacetonate; tetrabutylammomium bromide; sodium tert-butyl thiolate; silver nitrate;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane; decane; dichloromethane; water; N,N-dimethyl-formamide; acetone;
1: Suzuki coupling;
DOI:10.1016/j.bmc.2006.09.058
