2-(4-fluoro-2-(hydroxymethyl)phenoxy)-N-(2-oxo-1,2-dihydropyridin-4-yl)-4-(trifluoromethyl)benzamide

Base Information

Chemical Name:2-(4-fluoro-2-(hydroxymethyl)phenoxy)-N-(2-oxo-1,2-dihydropyridin-4-yl)-4-(trifluoromethyl)benzamide
CAS No.:1620847-62-2
Molecular Formula:C₂₀H₁₄F₄N₂O₄
Molecular Weight:422.336
Hs Code.:

Synonyms:2-(4-fluoro-2-(hydroxymethyl)phenoxy)-N-(2-oxo-1,2-dihydropyridin-4-yl)-4-(trifluoromethyl)benzamide

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Chemical Property of 2-(4-fluoro-2-(hydroxymethyl)phenoxy)-N-(2-oxo-1,2-dihydropyridin-4-yl)-4-(trifluoromethyl)benzamide

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Technology Process of 2-(4-fluoro-2-(hydroxymethyl)phenoxy)-N-(2-oxo-1,2-dihydropyridin-4-yl)-4-(trifluoromethyl)benzamide

There total 4 articles about 2-(4-fluoro-2-(hydroxymethyl)phenoxy)-N-(2-oxo-1,2-dihydropyridin-4-yl)-4-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 1.0%

: 1620847-66-6
2-fluoro-N-(2-oxo-1,2-dihydropyridin-4-yl)-4-(trifluoromethyl)benzamide

: 2357-33-7
5-fluoro-2-hydroxy-benzyl alcohol

: 1620847-62-2
2-(4-fluoro-2-(hydroxymethyl)phenoxy)-N-(2-oxo-1,2-dihydropyridin-4-yl)-4-(trifluoromethyl)benzamide

Guidance literature:: With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 0.166667h;

Reference yield:

: 1620847-67-7
2-fluoro-N-(2-methoxypyridin-4-yl)-4-(trifluoromethyl)benzamide

: 1620847-62-2
2-(4-fluoro-2-(hydroxymethyl)phenoxy)-N-(2-oxo-1,2-dihydropyridin-4-yl)-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide / acetic acid / 20 - 100 °C

2: potassium carbonate / 1-methyl-pyrrolidin-2-one / 0.17 h / 80 °C

With hydrogen bromide; potassium carbonate; In 1-methyl-pyrrolidin-2-one; acetic acid;

Reference yield:

: 20265-39-8
4-amino-2-methoxypyridine

: 1620847-62-2
2-(4-fluoro-2-(hydroxymethyl)phenoxy)-N-(2-oxo-1,2-dihydropyridin-4-yl)-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 0 - 20 °C

2: hydrogen bromide / acetic acid / 20 - 100 °C

3: potassium carbonate / 1-methyl-pyrrolidin-2-one / 0.17 h / 80 °C

With pyridine; hydrogen bromide; potassium carbonate; In 1-methyl-pyrrolidin-2-one; dichloromethane; acetic acid;