(2S,3R)-2-phenyl-3-(trifluoromethyl)piperazine

Base Information

Chemical Name:(2S,3R)-2-phenyl-3-(trifluoromethyl)piperazine
CAS No.:1612891-52-7
Molecular Formula:C₁₁H₁₃F₃N₂
Molecular Weight:230.233
Hs Code.:

Synonyms:(2S,3R)-2-phenyl-3-(trifluoromethyl)piperazine

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Chemical Property of (2S,3R)-2-phenyl-3-(trifluoromethyl)piperazine

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Technology Process of (2S,3R)-2-phenyl-3-(trifluoromethyl)piperazine

There total 12 articles about (2S,3R)-2-phenyl-3-(trifluoromethyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1612891-51-6
(2S,3R)-tert-butyl-3-phenyl-2-(trifluoromethyl)-piperazine-1-carboxylate

: 1612891-52-7
(2S,3R)-2-phenyl-3-(trifluoromethyl)piperazine

Guidance literature:: (2S,3R)-tert-butyl-3-phenyl-2-(trifluoromethyl)-piperazine-1-carboxylate; In methanol; at 20 ℃; for 18h; Inert atmosphere;

With ammonia; In methanol; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1021/jo500832j

Reference yield:

: 1612891-45-8
tert-butyl {[(2S,3R)-3-bis(4-methoxybenzyl)amino]-1,1,1-trifluoro-3-phenylpropan-2-yl}carbamate

: 1612891-52-7
(2S,3R)-2-phenyl-3-(trifluoromethyl)piperazine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 20% palladium hydroxide-activated charcoal; hydrogen / methanol

2.1: sodium hydrogencarbonate / ethyl acetate; water / 1.5 h / 0 °C / Inert atmosphere

3.1: sodium hydride; tetra-(n-butyl)ammonium iodide / tetrahydrofuran; mineral oil; N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.1: tetraphosphorus decasulfide / tetrahydrofuran / 0.5 h / 50 °C / Inert atmosphere

5.1: hydrogen / ethanol / 0.5 h / 20 °C

6.1: Amberlyst-15 / methanol / 18 h / 20 °C / Inert atmosphere

6.2: 5 h / 20 °C / Inert atmosphere

With tetraphosphorus decasulfide; 20% palladium hydroxide-activated charcoal; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; methanol; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo500832j

Reference yield:

: 1612891-46-9
tert-butyl [(2S,3R)-3-amino-1,1,1-trifluoro-3-phenylpropan-2-yl]carbamate

: 1612891-52-7
(2S,3R)-2-phenyl-3-(trifluoromethyl)piperazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / ethyl acetate; water / 1.5 h / 0 °C / Inert atmosphere

2.1: sodium hydride; tetra-(n-butyl)ammonium iodide / tetrahydrofuran; mineral oil; N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.1: tetraphosphorus decasulfide / tetrahydrofuran / 0.5 h / 50 °C / Inert atmosphere

4.1: hydrogen / ethanol / 0.5 h / 20 °C

5.1: Amberlyst-15 / methanol / 18 h / 20 °C / Inert atmosphere

5.2: 5 h / 20 °C / Inert atmosphere

With tetraphosphorus decasulfide; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; methanol; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo500832j