4-[3-(4-trifluoromethoxy-phenyl)-3,9-diaza-bicyclo[3.3.1]nonane-9-sulfonyl]-indan-2-carboxylic acid

Base Information

Chemical Name:4-[3-(4-trifluoromethoxy-phenyl)-3,9-diaza-bicyclo[3.3.1]nonane-9-sulfonyl]-indan-2-carboxylic acid
CAS No.:888326-81-6
Molecular Formula:C₂₄H₂₅F₃N₂O₅S
Molecular Weight:510.534
Hs Code.:

Synonyms:4-[3-(4-trifluoromethoxy-phenyl)-3,9-diaza-bicyclo[3.3.1]nonane-9-sulfonyl]-indan-2-carboxylic acid

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Chemical Property of 4-[3-(4-trifluoromethoxy-phenyl)-3,9-diaza-bicyclo[3.3.1]nonane-9-sulfonyl]-indan-2-carboxylic acid

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Technology Process of 4-[3-(4-trifluoromethoxy-phenyl)-3,9-diaza-bicyclo[3.3.1]nonane-9-sulfonyl]-indan-2-carboxylic acid

There total 11 articles about 4-[3-(4-trifluoromethoxy-phenyl)-3,9-diaza-bicyclo[3.3.1]nonane-9-sulfonyl]-indan-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 888327-48-8
4-[3-(4-trifluoromethoxy-phenyl)-3,9-diaza-bicyclo[3.3.1]nonane-9-sulfonyl]-indan-2-carboxylic acid methyl ester

: 888326-81-6
4-[3-(4-trifluoromethoxy-phenyl)-3,9-diaza-bicyclo[3.3.1]nonane-9-sulfonyl]-indan-2-carboxylic acid

Guidance literature:: 4-[3-(4-trifluoromethoxy-phenyl)-3,9-diaza-bicyclo[3.3.1]nonane-9-sulfonyl]-indan-2-carboxylic acid methyl ester; With methanol; lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield:

: cis-1-benzyl-piperidine-2,6-dicarboxylic acid hydrochloride

: 888326-81-6
4-[3-(4-trifluoromethoxy-phenyl)-3,9-diaza-bicyclo[3.3.1]nonane-9-sulfonyl]-indan-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,1'-carbonyldiimidazole / 1,4-dioxane / 0.25 h / 20 - 100 °C

1.2: 3 h

2.1: hydrogen / palladium 10% on activated carbon / ethanol; ethyl acetate / 18 h

3.1: dimethylsulfide borane complex / tetrahydrofuran / 0.67 h / 70 °C

3.2: 0.5 h

4.1: potassium carbonate / acetonitrile / 2 h / 50 °C

5.1: methanol; lithium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

With methanol; lithium hydroxide; dimethylsulfide borane complex; water; hydrogen; potassium carbonate; 1,1'-carbonyldiimidazole; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; ethyl acetate; acetonitrile;

Reference yield:

: 888327-26-2
dimethyl 4-nitro-1,3-dihydro-2H-indene-2,2-dicarboxylate

: 888326-81-6
4-[3-(4-trifluoromethoxy-phenyl)-3,9-diaza-bicyclo[3.3.1]nonane-9-sulfonyl]-indan-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; lithium chloride / dimethyl sulfoxide / 2 h / 160 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h / 2844.39 Torr

3.1: hydrogenchloride; sodium nitrite / water; acetonitrile / 0.67 h / -5 °C

3.2: 0.5 h / 55 °C

3.3: 3 - 10 °C

4.1: potassium carbonate / acetonitrile / 2 h / 50 °C

5.1: methanol; lithium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

With hydrogenchloride; methanol; lithium hydroxide; water; hydrogen; potassium carbonate; lithium chloride; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; water; dimethyl sulfoxide; ethyl acetate; acetonitrile;