N_ε-Boc-N_α-[(2R)-1-(3-(2,4-dichlorophenyl)ureido)-3-phenylpropan-2-yl]lysine benzyl amide

Base Information

• Chemical Name: N_ε-Boc-N_α-[(2R)-1-(3-(2,4-dichlorophenyl)ureido)-3-phenylpropan-2-yl]lysine benzyl amide
• CAS No.: 1416442-30-2
• Molecular Formula: C₃₄H₄₃Cl₂N₅O₄
• Molecular Weight: 656.653

Synonyms:N_ε-Boc-N_α-[(2R)-1-(3-(2,4-dichlorophenyl)ureido)-3-phenylpropan-2-yl]lysine benzyl amide

Chemical Property of N_ε-Boc-N_α-[(2R)-1-(3-(2,4-dichlorophenyl)ureido)-3-phenylpropan-2-yl]lysine benzyl amide

Chemical Property:

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Technology Process of N_ε-Boc-N_α-[(2R)-1-(3-(2,4-dichlorophenyl)ureido)-3-phenylpropan-2-yl]lysine benzyl amide

There total 2 articles about N_ε-Boc-N_α-[(2R)-1-(3-(2,4-dichlorophenyl)ureido)-3-phenylpropan-2-yl]lysine benzyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2,4-dichlorophenyl isocyanate (2612-57-9) + Nε-Boc-Nα-[(2R)-3-phenyl-1-(Fmoc)amino-propan-2-yl]lysine benzyl amide (1416442-10-8) → Nε-Boc-Nα-[(2R)-1-(3-(2,4-dichlorophenyl)ureido)-3-phenylpropan-2-yl]lysine benzyl amide (1416442-30-2)

Guidance literature:

N_ε-Boc-N_α-[(2R)-3-phenyl-1-(Fmoc)amino-propan-2-yl]lysine benzyl amide; With diethylamine; In dichloromethane; at 20 ℃; for 2h;

2,4-dichlorophenyl isocyanate; In dichloromethane; at 0 ℃;

DOI:10.1016/j.ejmech.2012.10.015

Reference yield:

C27H36N4O3 → Nε-Boc-Nα-[(2R)-1-(3-(2,4-dichlorophenyl)ureido)-3-phenylpropan-2-yl]lysine benzyl amide (1416442-30-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol / 0.08 h / Reflux

1.2: 2 h

2.1: diethylamine / dichloromethane / 2 h / 20 °C

2.2: 0 °C

With diethylamine; In methanol; dichloromethane;

DOI:10.1016/j.ejmech.2012.10.015

Reference yield: 100.0%

Nε-Boc-Nα-[(2R)-1-(3-(2,4-dichlorophenyl)ureido)-3-phenylpropan-2-yl]lysine benzyl amide (1416442-30-2) → Nα-[(2R)-1-(3-(2,4-dichlorophenyl)ureido)-3-phenylpropan-2-yl]lysine benzyl amide dihydrochloride

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2012.10.015

upstream raw materials:

2,4-dichlorophenyl isocyanate

N_ε-Boc-N_α-[(2R)-3-phenyl-1-(Fmoc)amino-propan-2-yl]lysine benzyl amide

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