ethyl 2-methyl-4-{N-(2-methylpropyl)-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyrimidine-5-carboxylate

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Chemical Name:ethyl 2-methyl-4-{N-(2-methylpropyl)-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyrimidine-5-carboxylate
CAS No.:157361-02-9
Molecular Formula:C₂₆H₂₉N₇O₂
Molecular Weight:471.562
Hs Code.:

Synonyms:ethyl 2-methyl-4-{N-(2-methylpropyl)-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyrimidine-5-carboxylate

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Chemical Property of ethyl 2-methyl-4-{N-(2-methylpropyl)-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyrimidine-5-carboxylate

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Technology Process of ethyl 2-methyl-4-{N-(2-methylpropyl)-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyrimidine-5-carboxylate

There total 5 articles about ethyl 2-methyl-4-{N-(2-methylpropyl)-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 141872-32-4
ethyl 2-methyl-4-{N-(2-methylpropyl)-N-[(2'-[N-triphenylmethyl-1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyrimidine-5-carboxylate

: 157361-02-9
ethyl 2-methyl-4-{N-(2-methylpropyl)-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyrimidine-5-carboxylate

Guidance literature:: With acetic acid; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 4-{Isobutyl-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-2-methyl-pyrimidine-5-carboxylic acid ethyl ester

: 157361-02-9
4-{Isobutyl-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-2-methyl-pyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: With formic acid; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jm00070a012

Reference yield:

: 2134-36-3
ethyl 4-chloro-2-methylpyrimidine-5-carboxylate

: 157361-02-9
4-{Isobutyl-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-2-methyl-pyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / tetrahydrofuran / 2 h

2: 88percent aq. HCOOH / CH₂Cl₂ / 2 h / Ambient temperature

With formic acid; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00070a012