3,5-Dimethyl-4-(2-hydroxyethyl)isoxazole

Base Information

• Chemical Name: 3,5-Dimethyl-4-(2-hydroxyethyl)isoxazole
• CAS No.: 83467-34-9
• Molecular Formula: C7H11 N O2
• Molecular Weight: 141.17
• Hs Code.: 2934999090
• Mol file: 83467-34-9.mol

Synonyms:2-(3,5-dimethylisoxazol-4-yl)ethanol

Chemical Property of 3,5-Dimethyl-4-(2-hydroxyethyl)isoxazole

Chemical Property:

• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.494
• Boiling Point: 266.261°C at 760 mmHg
• Flash Point: 114.831°C
• PSA: 46.26000
• Density: 1.1g/cm³
• LogP: 0.82620

Purity/Quality:

98%min ^*data from raw suppliers

2-(3,5-dimethylisoxazol-4-yl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Dimethyl-4-(2-hydroxyethyl)isoxazole

There total 6 articles about 3,5-Dimethyl-4-(2-hydroxyethyl)isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl 2-(3,5-dimethylisoxazol-4-yl)acetate (113618-89-6) → 3,5-dimethyl-4-(2-hydroxyethyl)isoxazole (83467-34-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1002/asia.201500447

Reference yield: 67.0%

methyl 2-(3,5-dimethylisoxazol-4-yl)acetate → 3,5-dimethyl-4-(2-hydroxyethyl)isoxazole (83467-34-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 25 ℃; for 1h;

Reference yield: 53.0%

1,1-diacetylcyclopropane (695-70-5) → 3,5-dimethyl-4-(2-hydroxyethyl)isoxazole (83467-34-9)

Guidance literature:

With hydroxyammonium sulfate; In methanol; water; Heating;

DOI:10.1016/0040-4020(82)80149-X

upstream raw materials:

1,1-diacetylcyclopropane

ethyl 3-acetyl-4-oxopentanoate

ethyl 2-(3,5-dimethylisoxazol-4-yl)acetate

4-chloromethyl-3,5-dimethylisoxazole

Refernces

• 1、 -. "HYDROXYL PURINE COMPOUNDS AND USE THEREOF". . . Retrieved 2018/04/05.
• 2、 Zefirov, Nikolai S.,Kozhushkov, Sergei I.,Kuznetsova, Tamara S.. "REARRANGEMENTS AND CYCLIZATIONS - XIV. RING-OPENING REACTIONS OF 1,1-DIACETYLCYCLOPROPANE WITH HYDRAZINE AND HYDROXYLAMINE DERIVATIVES AS THE NOVEL SYNTHESIS OF Β-X-ETHYL SUBSTITUTED PYRAZOLES AND ISOXAZOLES". . p. 1693 - 1697. Retrieved 2007/10/02.