1-((2R)-2-Cyclohexyl-2-hydroxyethanoyl)-N-(2-(1-amino-2,2-difluoroethyl)-5-chlorobenzyl)-L-prolinamide

Base Information

Chemical Name:1-((2R)-2-Cyclohexyl-2-hydroxyethanoyl)-N-(2-(1-amino-2,2-difluoroethyl)-5-chlorobenzyl)-L-prolinamide
CAS No.:439115-48-7
Molecular Formula:C₂₂H₃₀ClF₂N₃O₃
Molecular Weight:457.948
Hs Code.:

Synonyms:1-((2R)-2-Cyclohexyl-2-hydroxyethanoyl)-N-(2-(1-amino-2,2-difluoroethyl)-5-chlorobenzyl)-L-prolinamide

Suppliers and Price of 1-((2R)-2-Cyclohexyl-2-hydroxyethanoyl)-N-(2-(1-amino-2,2-difluoroethyl)-5-chlorobenzyl)-L-prolinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-((2R)-2-Cyclohexyl-2-hydroxyethanoyl)-N-(2-(1-amino-2,2-difluoroethyl)-5-chlorobenzyl)-L-prolinamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-((2R)-2-Cyclohexyl-2-hydroxyethanoyl)-N-(2-(1-amino-2,2-difluoroethyl)-5-chlorobenzyl)-L-prolinamide

There total 8 articles about 1-((2R)-2-Cyclohexyl-2-hydroxyethanoyl)-N-(2-(1-amino-2,2-difluoroethyl)-5-chlorobenzyl)-L-prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(5-chloro-2-{2,2-difluoro-1-[(4-methoxyphenyl)amino]ethyl}benzyl)-1-[(2R)-2-cyclohexyl-2-hydroxyethanoyl]-L-prolinamide

: 439115-48-7
1-((2R)-2-Cyclohexyl-2-hydroxyethanoyl)-N-(2-(1-amino-2,2-difluoroethyl)-5-chlorobenzyl)-L-prolinamide

Guidance literature:: With NH₄Ca(NO₃)3; ammonium hydroxide; In methanol; chloroform; water; acetonitrile;

Reference yield:

: (5-chloro-2-{2,2-difluoro-1-[(4-methoxyphenyl)amino]ethyl}phenyl)methanol

: 439115-48-7
1-((2R)-2-Cyclohexyl-2-hydroxyethanoyl)-N-(2-(1-amino-2,2-difluoroethyl)-5-chlorobenzyl)-L-prolinamide

Guidance literature:: Multi-step reaction with 6 steps

1: diphenyl-phosphinic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene

2: sodium hydroxide; triphenylphosphine / tetrahydrofuran; methanol; water

3: 1,2-dichloro-ethane / N,N-dimethyl-formamide

4: trifluoroacetic acid / dichloromethane

5: 1,2-dichloro-ethane / N,N-dimethyl-formamide

6: NH₄Ca(NO₃)3; ammonium hydroxide / methanol; chloroform; water; acetonitrile

With NH₄Ca(NO₃)3; ammonium hydroxide; sodium hydroxide; diphenyl-phosphinic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,2-dichloro-ethane; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: N-{1-[2-(azidomethyl)-4-chlorophenyl]-2,2-difluoroethyl}-N-(4-methoxyphenyl)amine

: 439115-48-7
1-((2R)-2-Cyclohexyl-2-hydroxyethanoyl)-N-(2-(1-amino-2,2-difluoroethyl)-5-chlorobenzyl)-L-prolinamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide; triphenylphosphine / tetrahydrofuran; methanol; water

2: 1,2-dichloro-ethane / N,N-dimethyl-formamide

3: trifluoroacetic acid / dichloromethane

4: 1,2-dichloro-ethane / N,N-dimethyl-formamide

5: NH₄Ca(NO₃)3; ammonium hydroxide / methanol; chloroform; water; acetonitrile

With NH₄Ca(NO₃)3; ammonium hydroxide; sodium hydroxide; 1,2-dichloro-ethane; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile;