3-[1-(4-bromo-phenyl)-cyclobutyl]-cyclopenta-1,3-dienecarboxylic acid dimethylamide

Base Information

• Chemical Name: 3-[1-(4-bromo-phenyl)-cyclobutyl]-cyclopenta-1,3-dienecarboxylic acid dimethylamide
• CAS No.: 1361189-60-7
• Molecular Formula: C₁₅H₁₆BrN₃O₂
• Molecular Weight: 350.215
• Mol file: 1361189-60-7.mol

Synonyms:3-[1-(4-bromo-phenyl)-cyclobutyl]-cyclopenta-1,3-dienecarboxylic acid dimethylamide

Chemical Property of 3-[1-(4-bromo-phenyl)-cyclobutyl]-cyclopenta-1,3-dienecarboxylic acid dimethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[1-(4-bromo-phenyl)-cyclobutyl]-cyclopenta-1,3-dienecarboxylic acid dimethylamide

There total 3 articles about 3-[1-(4-bromo-phenyl)-cyclobutyl]-cyclopenta-1,3-dienecarboxylic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

monomethyl oxalyl chloride (5781-53-3) + oxo-pyrrolidin-1-yl-acetyl chloride (100481-08-1) + 1-(4-bromophenyl)-N-hydroxycyclobutanecarboxamidine (1361189-45-8) → 3-[1-(4-bromo-phenyl)-cyclobutyl]-cyclopenta-1,3-dienecarboxylic acid dimethylamide (1361189-60-7)

Guidance literature:

monomethyl oxalyl chloride; oxo-pyrrolidin-1-yl-acetyl chloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 0.5h;

1-(4-bromophenyl)-N-hydroxycyclobutanecarboxamidine; With pyridine; In tetrahydrofuran; at 50 ℃;

Reference yield:

4-Bromophenylacetonitrile (16532-79-9) → 3-[1-(4-bromo-phenyl)-cyclobutyl]-cyclopenta-1,3-dienecarboxylic acid dimethylamide (1361189-60-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 2 h / 0 °C

2.1: hydroxylamine / ethanol; water / 80 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C

3.2: 50 °C

With hydroxylamine; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

1-(4- bromophenyl)cyclobutane-1-carbonitrile (485828-58-8) → 3-[1-(4-bromo-phenyl)-cyclobutyl]-cyclopenta-1,3-dienecarboxylic acid dimethylamide (1361189-60-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydroxylamine / ethanol; water / 80 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C

2.2: 50 °C

With hydroxylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; water;

upstream raw materials:

4-Bromophenylacetonitrile

monomethyl oxalyl chloride

oxo-pyrrolidin-1-yl-acetyl chloride

1-(4-bromophenyl)-N-hydroxycyclobutanecarboxamidine