N-((1R,2S)-1-(4-(5-(aminomethyl)thiophen-2-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-dichloroacetamide

Base Information

Chemical Name:N-((1R,2S)-1-(4-(5-(aminomethyl)thiophen-2-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-dichloroacetamide
CAS No.:1454904-00-7
Molecular Formula:C₁₆H₁₇Cl₂FN₂O₂S
Molecular Weight:391.294
Hs Code.:

Synonyms:N-((1R,2S)-1-(4-(5-(aminomethyl)thiophen-2-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-dichloroacetamide

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Chemical Property of N-((1R,2S)-1-(4-(5-(aminomethyl)thiophen-2-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-dichloroacetamide

Chemical Property:

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Technology Process of N-((1R,2S)-1-(4-(5-(aminomethyl)thiophen-2-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-dichloroacetamide

There total 3 articles about N-((1R,2S)-1-(4-(5-(aminomethyl)thiophen-2-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-dichloroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454906-48-9
tert-butyl ((5-(4-((1R,2S)-2-(2,2-dichloroacetamido)-3-fluoro-1-hydroxypropyl)phenyl)thiophen-2-yl)methyl)carbamate

: 1454904-00-7
N-((1R,2S)-1-(4-(5-(aminomethyl)thiophen-2-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-dichloroacetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 215183-27-0
tert-butyl ((5-bromothiophen-2-yl)methyl)carbamate

: 1454904-00-7
N-((1R,2S)-1-(4-(5-(aminomethyl)thiophen-2-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-dichloroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride / toluene / 26 h / 90 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; cesium fluoride; trifluoroacetic acid; In dichloromethane; toluene;

Reference yield:

: 1431551-86-8
2,2-dichloro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(trimethylstannyl)phenyl)propan-2-yl)acetamide

: 1454904-00-7
N-((1R,2S)-1-(4-(5-(aminomethyl)thiophen-2-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-dichloroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride / toluene / 26 h / 90 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; cesium fluoride; trifluoroacetic acid; In dichloromethane; toluene;