N-(1-ethyl-1H-imidazol-4-yl)-3-((4-fluorophenyl)sulfonyl)isoquinolin-1-amine

Base Information

Chemical Name:N-(1-ethyl-1H-imidazol-4-yl)-3-((4-fluorophenyl)sulfonyl)isoquinolin-1-amine
CAS No.:1362689-43-7
Molecular Formula:C₂₀H₁₇FN₄O₂S
Molecular Weight:396.445
Hs Code.:

Synonyms:N-(1-ethyl-1H-imidazol-4-yl)-3-((4-fluorophenyl)sulfonyl)isoquinolin-1-amine

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Chemical Property of N-(1-ethyl-1H-imidazol-4-yl)-3-((4-fluorophenyl)sulfonyl)isoquinolin-1-amine

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Technology Process of N-(1-ethyl-1H-imidazol-4-yl)-3-((4-fluorophenyl)sulfonyl)isoquinolin-1-amine

There total 6 articles about N-(1-ethyl-1H-imidazol-4-yl)-3-((4-fluorophenyl)sulfonyl)isoquinolin-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1200606-60-5
1-ethyl-1H-imidazol-4-amine

: 1362689-83-5
1-chloro-3-((4-fluorophenyl)sulfonyl)isoquinoline

: 1362689-43-7
N-(1-ethyl-1H-imidazol-4-yl)-3-((4-fluorophenyl)sulfonyl)isoquinolin-1-amine

Guidance literature:: With sodium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; In toluene; at 130 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 7742-73-6
1,3-dichloroisoquinoline

: 1362689-43-7
N-(1-ethyl-1H-imidazol-4-yl)-3-((4-fluorophenyl)sulfonyl)isoquinolin-1-amine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium / acetonitrile / 1.5 h / 65 °C

2: CsCO₃ / ISOPROPYLAMIDE / 0.33 h / 100 °C / Sealed tube; Microwave irradiation

3: trichlorophosphate / toluene / 1 h / 120 °C / Sealed tube

4: 3-chloro-benzenecarboperoxoic acid / water / 5 h / 0 °C

5: sodium carbonate / 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 0.33 h / 130 °C / Inert atmosphere; Microwave irradiation

With CsCO₃; sodium; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; In ISOPROPYLAMIDE; water; toluene; acetonitrile;

Reference yield:

: 13230-05-2
1-ethyl-4-nitroimidazole

: 1362689-43-7
N-(1-ethyl-1H-imidazol-4-yl)-3-((4-fluorophenyl)sulfonyl)isoquinolin-1-amine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 4 h / 20 - 60 °C

2: sodium carbonate / 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 0.33 h / 130 °C / Inert atmosphere; Microwave irradiation

With hydrogen; sodium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; 10 wt% Pd(OH)2 on carbon; In ethanol; toluene;