(R)-1-(3-bromophenyl)prop-2-en-1-ol

Base Information

• Chemical Name: (R)-1-(3-bromophenyl)prop-2-en-1-ol
• CAS No.: 1282033-70-8
• Molecular Formula: C₉H₉BrO
• Molecular Weight: 213.074
• Mol file: 1282033-70-8.mol

Synonyms:(R)-1-(3-bromophenyl)prop-2-en-1-ol

Chemical Property of (R)-1-(3-bromophenyl)prop-2-en-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-(3-bromophenyl)prop-2-en-1-ol

There total 3 articles about (R)-1-(3-bromophenyl)prop-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

vinyl acetate (108-05-4,9003-20-7) + 1-(3-bromo-phenyl)-prop-2-en-1-ol (58824-55-8) → (R)-1-(3-bromophenyl)prop-2-en-1-ol (1282033-70-8) + (S)-1-(3-bromophenyl)prop-2-en-1-ol (1075178-72-1) + (R)-(+)-1-acetoxy-1-(3-bromophenyl)-2-propylene (1339947-98-6)

Guidance literature:

With lipase PS-30; In toluene; at 20 ℃; for 48h; optical yield given as %ee; enantioselective reaction; Molecular sieve; Inert atmosphere; Enzymatic reaction;

DOI:10.1016/j.tetlet.2011.08.093

Reference yield:

m-bromobenzoic aldehyde (3132-99-8) → (R)-1-(3-bromophenyl)prop-2-en-1-ol (1282033-70-8) + (S)-1-(3-bromophenyl)prop-2-en-1-ol (1075178-72-1) + (R)-(3-bromophenyl)((S)-oxiran-2-yl)methanol (1075178-88-9) + (1R,2R)-(3-bromophenyl)-2,3-glycidol (1282033-78-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / Cooling

2: Escherichia coli BL₂₁ harboring the plasmid pET₂₈a(+) encoding the styAB gene from Pseudomonas sp. LQ₂₆ / 48 h / pH 6.5 / aq. phosphate buffer; Enzymatic reaction

With Escherichia coli BL₂₁ harboring the plasmid pET₂₈a(+) encoding the styAB gene from Pseudomonas sp. LQ₂₆; In tetrahydrofuran;

DOI:10.1039/c0cc04360e

Reference yield:

1-(3-bromo-phenyl)-prop-2-en-1-ol (58824-55-8) → (R)-1-(3-bromophenyl)prop-2-en-1-ol (1282033-70-8) + (S)-1-(3-bromophenyl)prop-2-en-1-ol (1075178-72-1) + (R)-(3-bromophenyl)((S)-oxiran-2-yl)methanol (1075178-88-9) + (1R,2R)-(3-bromophenyl)-2,3-glycidol (1282033-78-6)

Guidance literature:

With Escherichia coli BL₂₁ harboring the plasmid pET₂₈a(+) encoding the styAB gene from Pseudomonas sp. LQ₂₆; for 48h; pH=6.5; optical yield given as %ee; enantioselective reaction; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1039/c0cc04360e

upstream raw materials:

m-bromobenzoic aldehyde

1-(3-bromo-phenyl)-prop-2-en-1-ol

vinyl acetate