dimethylamide of N-benzyloxycarbonyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-methionine

Base Information

• Chemical Name: dimethylamide of N-benzyloxycarbonyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-methionine
• CAS No.: 94847-52-6
• Molecular Formula: C₃₇H₄₆N₆O₈S
• Molecular Weight: 734.874
• Mol file: 94847-52-6.mol

Synonyms:dimethylamide of N-benzyloxycarbonyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-methionine

Chemical Property of dimethylamide of N-benzyloxycarbonyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-methionine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethylamide of N-benzyloxycarbonyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-methionine

There total 3 articles about dimethylamide of N-benzyloxycarbonyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-methionine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4,6-trichlorophenyl ester of N-t-butyloxycarbonyl-L-methionine → dimethylamide of N-benzyloxycarbonyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-methionine (94847-52-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / tetrahydrofuran / 4 h

2: 1.) NH₃ / 1.) CHCl₃, 2.) THF, AcOH, 20 h

3: 1.) 4 M aq. HCl, 2.) diphenylphosphoric acid azide, Et₃N / 1.) dioxane, 2.) DMF, a) 2 h, b) RT, 19 h

With hydrogenchloride; diphenyl phosphoryl azide; ammonia; triethylamine; In tetrahydrofuran;

Reference yield:

hydrochloride of dimethylamide of L-methionine → dimethylamide of N-benzyloxycarbonyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-methionine (94847-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NH₃ / 1.) CHCl₃, 2.) THF, AcOH, 20 h

2: 1.) 4 M aq. HCl, 2.) diphenylphosphoric acid azide, Et₃N / 1.) dioxane, 2.) DMF, a) 2 h, b) RT, 19 h

With hydrogenchloride; diphenyl phosphoryl azide; ammonia; triethylamine;

Reference yield:

N-[N-(N-benzyloxycarbonyl-L-tyrosyl)-glycyl]-glycine (74072-21-2) + dimethylamide of N-t-butyloxycarbonyl-L-phenylalanyl-L-methionine (94847-40-2) → dimethylamide of N-benzyloxycarbonyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-methionine (94847-52-6)

Guidance literature:

With hydrogenchloride; diphenyl phosphoryl azide; triethylamine; Yield given. Multistep reaction; 1.) dioxane, 2.) DMF, a) 2 h, b) RT, 19 h;

upstream raw materials:

N-[N-(N-benzyloxycarbonyl-L-tyrosyl)-glycyl]-glycine

dimethylamide of N-t-butyloxycarbonyl-L-phenylalanyl-L-methionine

Downstream raw materials:

N-benzyloxycarbonyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-methionylsulfone dimethylamide

dimethylamide of L-tyrosylglycylglycyl-L-phenylalanyl-L-methionine

L-tyrosylglycylglycyl-L-phenylalanyl-L-methionylsulfone dimethylamide diacetate