6-chloro-3-(3-chlorophenylsulfonyl)-N₂,5-dimethylpyrazolo[1,5-a ]pyrimidine-2,7-diamine

Base Information

• Chemical Name: 6-chloro-3-(3-chlorophenylsulfonyl)-N₂,5-dimethylpyrazolo[1,5-a ]pyrimidine-2,7-diamine
• CAS No.: 1345973-63-8
• Molecular Formula: C₁₄H₁₃Cl₂N₅O₂S
• Molecular Weight: 386.262

Synonyms:6-chloro-3-(3-chlorophenylsulfonyl)-N₂,5-dimethylpyrazolo[1,5-a ]pyrimidine-2,7-diamine

Chemical Property of 6-chloro-3-(3-chlorophenylsulfonyl)-N₂,5-dimethylpyrazolo[1,5-a ]pyrimidine-2,7-diamine

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Technology Process of 6-chloro-3-(3-chlorophenylsulfonyl)-N₂,5-dimethylpyrazolo[1,5-a ]pyrimidine-2,7-diamine

There total 3 articles about 6-chloro-3-(3-chlorophenylsulfonyl)-N₂,5-dimethylpyrazolo[1,5-a ]pyrimidine-2,7-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

6,7-dichloro-3-(3-chlorophenylsulfonyl)-N,5-dimethylpyrazolo[1,5-a]pyrimidin-2-amine (1345973-76-3) → 6-chloro-3-(3-chlorophenylsulfonyl)-N2,5-dimethylpyrazolo[1,5-a ]pyrimidine-2,7-diamine (1345973-63-8)

Guidance literature:

With ammonia; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1021/jm201079g

Reference yield:

6-chloro-3-(3-chlorophenylsulfonyl)-5-methyl-2-(methylamino)pyrazolo[1,5-a]pyrimidin-7-ol (1345973-70-7) → 6-chloro-3-(3-chlorophenylsulfonyl)-N2,5-dimethylpyrazolo[1,5-a ]pyrimidine-2,7-diamine (1345973-63-8)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / sulfolane / 3 h / 70 °C

2: ammonia / tetrahydrofuran / 12 h / 20 °C

With ammonia; trichlorophosphate; In tetrahydrofuran; sulfolane;

DOI:10.1021/jm201079g

Reference yield:

C10H11ClN4O2S → 6-chloro-3-(3-chlorophenylsulfonyl)-N2,5-dimethylpyrazolo[1,5-a ]pyrimidine-2,7-diamine (1345973-63-8)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 20 - 100 °C

2: trichlorophosphate / sulfolane / 3 h / 70 °C

3: ammonia / tetrahydrofuran / 12 h / 20 °C

With ammonia; acetic acid; trichlorophosphate; In tetrahydrofuran; sulfolane;

DOI:10.1021/jm201079g

upstream raw materials:

6-chloro-3-(3-chlorophenylsulfonyl)-5-methyl-2-(methylamino)pyrazolo[1,5-a]pyrimidin-7-ol

6,7-dichloro-3-(3-chlorophenylsulfonyl)-N,5-dimethylpyrazolo[1,5-a]pyrimidin-2-amine

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