2-tert-butoxycarbonylamino-propionic acid 3-(3-hydroxy-prop-1-ynyl)-2-{4-phenyl-3-[(toluene-4-sulfonylamino)-methyl]-but-3-en-1-ynyl}-benzyl ester

Base Information

Chemical Name:2-tert-butoxycarbonylamino-propionic acid 3-(3-hydroxy-prop-1-ynyl)-2-{4-phenyl-3-[(toluene-4-sulfonylamino)-methyl]-but-3-en-1-ynyl}-benzyl ester
CAS No.:1421947-69-4
Molecular Formula:C₃₆H₃₈N₂O₇S
Molecular Weight:642.773
Hs Code.:

2-tert-butoxycarbonylamino-propionic acid 3-(3-hydroxy-prop-1-ynyl)-2-{4-phenyl-3-[(toluene-4-sulfonylamino)-methyl]-but-3-en-1-ynyl}-benzyl ester

Synonyms:2-tert-butoxycarbonylamino-propionic acid 3-(3-hydroxy-prop-1-ynyl)-2-{4-phenyl-3-[(toluene-4-sulfonylamino)-methyl]-but-3-en-1-ynyl}-benzyl ester

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Chemical Property of 2-tert-butoxycarbonylamino-propionic acid 3-(3-hydroxy-prop-1-ynyl)-2-{4-phenyl-3-[(toluene-4-sulfonylamino)-methyl]-but-3-en-1-ynyl}-benzyl ester

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Technology Process of 2-tert-butoxycarbonylamino-propionic acid 3-(3-hydroxy-prop-1-ynyl)-2-{4-phenyl-3-[(toluene-4-sulfonylamino)-methyl]-but-3-en-1-ynyl}-benzyl ester

There total 14 articles about 2-tert-butoxycarbonylamino-propionic acid 3-(3-hydroxy-prop-1-ynyl)-2-{4-phenyl-3-[(toluene-4-sulfonylamino)-methyl]-but-3-en-1-ynyl}-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1421947-65-0
C₄₁H₄₆N₂O₈S

: 1421947-69-4
2-tert-butoxycarbonylamino-propionic acid 3-(3-hydroxy-prop-1-ynyl)-2-{4-phenyl-3-[(toluene-4-sulfonylamino)-methyl]-but-3-en-1-ynyl}-benzyl ester

Guidance literature:: With pyridinium p-toluenesulfonate; In ethanol; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1016/j.tet.2012.12.064

Reference yield:

: 1421947-63-8
C₉H₈IN₃

: 1421947-69-4
2-tert-butoxycarbonylamino-propionic acid 3-(3-hydroxy-prop-1-ynyl)-2-{4-phenyl-3-[(toluene-4-sulfonylamino)-methyl]-but-3-en-1-ynyl}-benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; water / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / tetrahydrofuran / 20 °C / Inert atmosphere

4: pyridinium p-toluenesulfonate / ethanol / 6 h / 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; pyridinium p-toluenesulfonate; triethylamine; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; 3: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tet.2012.12.064

Reference yield:

: 1421947-64-9
C₉H₁₀IN

: 1421947-69-4
2-tert-butoxycarbonylamino-propionic acid 3-(3-hydroxy-prop-1-ynyl)-2-{4-phenyl-3-[(toluene-4-sulfonylamino)-methyl]-but-3-en-1-ynyl}-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / tetrahydrofuran / 20 °C / Inert atmosphere

3: pyridinium p-toluenesulfonate / ethanol / 6 h / 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; pyridinium p-toluenesulfonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; 2: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tet.2012.12.064