1-(5,5-bis(4-fluorophenyl)pentyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol

Base Information

Chemical Name:1-(5,5-bis(4-fluorophenyl)pentyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol
CAS No.:1266656-45-4
Molecular Formula:C₂₉H₂₉ClF₅NO
Molecular Weight:538
Hs Code.:

Synonyms:1-(5,5-bis(4-fluorophenyl)pentyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(5,5-bis(4-fluorophenyl)pentyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol

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Technology Process of 1-(5,5-bis(4-fluorophenyl)pentyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol

There total 9 articles about 1-(5,5-bis(4-fluorophenyl)pentyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 21928-50-7
4-[4-chloro-3-trifluoromethylphenyl]-4-piperidinol

: 120737-86-2
4,4'-(5-bromopentane-1,1-diyl)bis(fluorobenzene)

: 1266656-45-4
1-(5,5-bis(4-fluorophenyl)pentyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol

Guidance literature:: With sodium carbonate; potassium iodide; In acetonitrile; for 12h; Reflux;
DOI:10.1016/j.bmcl.2018.10.036

Reference yield:

: 445-01-2
5-bromo-2-chlorobenzotrifluoride

: 1266656-45-4
1-(5,5-bis(4-fluorophenyl)pentyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium; iodine / tetrahydrofuran / 2 h / 50 °C

1.2: 3 h / 20 °C / Reflux

2.1: hydrogenchloride / ethanol / 16 h / 50 °C

3.1: sodium carbonate; potassium iodide / acetonitrile / 12 h / Reflux

With hydrogenchloride; iodine; sodium carbonate; magnesium; potassium iodide; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1016/j.bmcl.2018.10.036

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1266656-45-4
1-(5,5-bis(4-fluorophenyl)pentyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium; iodine / tetrahydrofuran / 2 h / 50 °C

1.2: 3 h / 20 °C / Reflux

2.1: hydrogenchloride / ethanol / 16 h / 50 °C

3.1: sodium carbonate; potassium iodide / acetonitrile / 12 h / Reflux

With hydrogenchloride; iodine; sodium carbonate; magnesium; potassium iodide; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1016/j.bmcl.2018.10.036