1-{6-[2-({[2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}oxy)-5-(trifluoromethyl)phenyl]-2-pyridinyl}-4-piperidinecarboxylic acid

Base Information

Chemical Name:1-{6-[2-({[2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}oxy)-5-(trifluoromethyl)phenyl]-2-pyridinyl}-4-piperidinecarboxylic acid
CAS No.:1160431-81-1
Molecular Formula:C₃₂H₃₆BF₃N₂O₅
Molecular Weight:596.454
Hs Code.:

1-{6-[2-({[2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}oxy)-5-(trifluoromethyl)phenyl]-2-pyridinyl}-4-piperidinecarboxylic acid

Synonyms:1-{6-[2-({[2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}oxy)-5-(trifluoromethyl)phenyl]-2-pyridinyl}-4-piperidinecarboxylic acid

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Chemical Property of 1-{6-[2-({[2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}oxy)-5-(trifluoromethyl)phenyl]-2-pyridinyl}-4-piperidinecarboxylic acid

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Technology Process of 1-{6-[2-({[2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}oxy)-5-(trifluoromethyl)phenyl]-2-pyridinyl}-4-piperidinecarboxylic acid

There total 1 articles about 1-{6-[2-({[2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}oxy)-5-(trifluoromethyl)phenyl]-2-pyridinyl}-4-piperidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.2%

: 1160431-78-6
ethyl 1-{6-[2-({[2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}oxy)-5-(trifluoromethyl)phenyl]-2-pyridinyl}-4-piperidinecarboxylate

: 1160431-81-1
1-{6-[2-({[2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}oxy)-5-(trifluoromethyl)phenyl]-2-pyridinyl}-4-piperidinecarboxylic acid

Guidance literature:: ethyl 1-{6-[2-({[2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}oxy)-5-(trifluoromethyl)phenyl]-2-pyridinyl}-4-piperidinecarboxylate; With sodium hydroxide; ethanol; water; In tetrahydrofuran; at 20 ℃; for 1h;

With hydrogenchloride; water; pH=~ 6;

Reference yield: 46.9%

: 1160431-81-1
1-{6-[2-({[2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}oxy)-5-(trifluoromethyl)phenyl]-2-pyridinyl}-4-piperidinecarboxylic acid

: 139585-70-9
2-bromo-5-cyanopyridine

: 1160430-22-7
1-[6-(5-trifluoromethyl-2-(2-methyl-4-(5-cyanopyridin-2-yl)benzyloxy)-phenyl)pyridin-2-yl]-piperidine-4-carboxylic acid

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 72h; Heating / reflux;