(+)-(1R,2S,3R)-methyl 3-hydroxy-2-(2-triphenylmethoxyethyl)-1-cyclopentaneacetate

Base Information

Chemical Name:(+)-(1R,2S,3R)-methyl 3-hydroxy-2-(2-triphenylmethoxyethyl)-1-cyclopentaneacetate
CAS No.:139448-28-5
Molecular Formula:C₂₉H₃₂O₄
Molecular Weight:444.571
Hs Code.:

Synonyms:(+)-(1R,2S,3R)-methyl 3-hydroxy-2-(2-triphenylmethoxyethyl)-1-cyclopentaneacetate

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Chemical Property of (+)-(1R,2S,3R)-methyl 3-hydroxy-2-(2-triphenylmethoxyethyl)-1-cyclopentaneacetate

Chemical Property:

Purity/Quality:

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Technology Process of (+)-(1R,2S,3R)-methyl 3-hydroxy-2-(2-triphenylmethoxyethyl)-1-cyclopentaneacetate

There total 13 articles about (+)-(1R,2S,3R)-methyl 3-hydroxy-2-(2-triphenylmethoxyethyl)-1-cyclopentaneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 76-83-5
trityl chloride

: 139448-27-4
(+)-(1R,2S,3R)-methyl 3-hydroxy-2-(2-hydroxyethyl)-1-cyclopentaneacetate

: 139448-28-5
(+)-(1R,2S,3R)-methyl 3-hydroxy-2-(2-triphenylmethoxyethyl)-1-cyclopentaneacetate

Guidance literature:: With pyridine; dmap; In dichloromethane; Heating;

Reference yield:

: 90534-01-3
(+/-)-bicyclo[4.3.0]non-3-en-7-on

: 139448-28-5
(+)-(1R,2S,3R)-methyl 3-hydroxy-2-(2-triphenylmethoxyethyl)-1-cyclopentaneacetate

Guidance literature:: Multi-step reaction with 11 steps

1: 95 percent / NaBH₄, CeCl₃ * 7 H₂O / methanol / 1 h / -70 °C

2: 83 percent / NBS / tetrahydrofuran

3: 76 percent / Zn, NH₄Cl / aq. ethanol / 5 h / Heating

4: hexane / 40 h / 30 °C / lipase MY

5: KOH / methanol

6: 1) O₃, 2) Ph₃P / 1) CH₂Cl₂, -70 deg C, 2) rt, overnight

7: 66 percent / KMnO₄, MgSO₄ / acetone; H₂O / 5 h / 0 °C

8: 100 percent

9: 77 percent / 30percent acetic acid / 0.5 h / 60 °C

10: 84 percent / NaBH₄, CeCl₃ * 7H₂O / methanol / 5 h / -10 °C

11: 91 percent / pyridine, DMAP / CH₂Cl₂ / Heating

With pyridine; dmap; potassium hydroxide; sodium tetrahydroborate; potassium permanganate; N-Bromosuccinimide; cerium(III) chloride; magnesium sulfate; ammonium chloride; ozone; acetic acid; triphenylphosphine; zinc; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; acetone;

Reference yield:

: 139448-23-0
(1R,2R,4R,7R,8S)-2-Bromo-10-oxa-tricyclo[5.2.1.0^4,8]decane

: 139448-28-5
(+)-(1R,2S,3R)-methyl 3-hydroxy-2-(2-triphenylmethoxyethyl)-1-cyclopentaneacetate

Guidance literature:: Multi-step reaction with 9 steps

1: 76 percent / Zn, NH₄Cl / aq. ethanol / 5 h / Heating

2: hexane / 40 h / 30 °C / lipase MY

3: KOH / methanol

4: 1) O₃, 2) Ph₃P / 1) CH₂Cl₂, -70 deg C, 2) rt, overnight

5: 66 percent / KMnO₄, MgSO₄ / acetone; H₂O / 5 h / 0 °C

6: 100 percent

7: 77 percent / 30percent acetic acid / 0.5 h / 60 °C

8: 84 percent / NaBH₄, CeCl₃ * 7H₂O / methanol / 5 h / -10 °C

9: 91 percent / pyridine, DMAP / CH₂Cl₂ / Heating

With pyridine; dmap; potassium hydroxide; sodium tetrahydroborate; potassium permanganate; cerium(III) chloride; magnesium sulfate; ammonium chloride; ozone; acetic acid; triphenylphosphine; zinc; In methanol; ethanol; hexane; dichloromethane; water; acetone;