3-[(2-N-methyl-N-(4-nitrophenyl)-N-methylamino)ethyl]-4-oxo-3H,4H-imidazo[1,5-d][1,2,3,5]tetrazine-8-carboxamide

Base Information

Chemical Name:3-[(2-N-methyl-N-(4-nitrophenyl)-N-methylamino)ethyl]-4-oxo-3H,4H-imidazo[1,5-d][1,2,3,5]tetrazine-8-carboxamide
CAS No.:1190761-84-2
Molecular Formula:C₁₄H₁₄N₈O₄
Molecular Weight:358.316
Hs Code.:

Synonyms:3-[(2-N-methyl-N-(4-nitrophenyl)-N-methylamino)ethyl]-4-oxo-3H,4H-imidazo[1,5-d][1,2,3,5]tetrazine-8-carboxamide

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Chemical Property of 3-[(2-N-methyl-N-(4-nitrophenyl)-N-methylamino)ethyl]-4-oxo-3H,4H-imidazo[1,5-d][1,2,3,5]tetrazine-8-carboxamide

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Technology Process of 3-[(2-N-methyl-N-(4-nitrophenyl)-N-methylamino)ethyl]-4-oxo-3H,4H-imidazo[1,5-d][1,2,3,5]tetrazine-8-carboxamide

There total 7 articles about 3-[(2-N-methyl-N-(4-nitrophenyl)-N-methylamino)ethyl]-4-oxo-3H,4H-imidazo[1,5-d][1,2,3,5]tetrazine-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1190762-13-0
2-[(4-nitrophenyl)methylamino]ethylisocyanate

: 7008-85-7
5-diazoimidazole-4-carboxamide

: 1190761-84-2
3-[(2-N-methyl-N-(4-nitrophenyl)-N-methylamino)ethyl]-4-oxo-3H,4H-imidazo[1,5-d][1,2,3,5]tetrazine-8-carboxamide

Guidance literature:: In dimethyl sulfoxide; at 20 ℃; for 48h; Inert atmosphere; Light absence;

Reference yield:

: 1190762-04-9
3(N-methyl-N-(2-nitrophenyl)amino)propanoyl azide

: 1190761-84-2
3-[(2-N-methyl-N-(4-nitrophenyl)-N-methylamino)ethyl]-4-oxo-3H,4H-imidazo[1,5-d][1,2,3,5]tetrazine-8-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; sodium nitrite / dichloromethane; water / 0 - 5 °C

2: dichloromethane / 20 °C / Inert atmosphere

3: dimethyl sulfoxide / 48 h / 20 °C / Inert atmosphere; Light absence

With hydrogenchloride; sodium nitrite; In dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 100-15-2
N-methyl(p-nitroaniline)

: 1190761-84-2
3-[(2-N-methyl-N-(4-nitrophenyl)-N-methylamino)ethyl]-4-oxo-3H,4H-imidazo[1,5-d][1,2,3,5]tetrazine-8-carboxamide

: 1450610-20-4
3-[(2-N-methyl-N-(2-nitrophenyl)-N-methylamino)ethyl]-4-oxo-3H,4H-imidazo[1,5-d][1,2,3,5]tetrazine-8-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: copper(l) chloride; acetic acid / 2 h / 160 °C

2: hydrazine hydrate / isopropyl alcohol / 48 h / 20 °C

3: hydrogenchloride; sodium nitrite / water; dichloromethane / 0 - 5 °C

4: dichloromethane / 20 °C / Inert atmosphere

5: dimethyl sulfoxide / 48 h / 20 °C / Inert atmosphere; Darkness

With hydrogenchloride; hydrazine hydrate; acetic acid; copper(l) chloride; sodium nitrite; In dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol; 4: |Curtius Rearrangement;
DOI:10.1021/jm401121k