2-(((4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-benzimidazole

Base Information

Chemical Name:2-(((4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-benzimidazole
CAS No.:913696-27-2
Molecular Formula:C₂₂H₂₇N₃O₃S
Molecular Weight:413.541
Hs Code.:

Synonyms:2-(((4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-benzimidazole

Suppliers and Price of 2-(((4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-benzimidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(((4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-benzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(((4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-benzimidazole

There total 2 articles about 2-(((4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.5%

: 4728-12-5
2,2-dimethyl-5-hydroxymethyl-1,3-dioxane

: 1020086-02-5
2-(4-chloro-3,5-dimethylpyridin-2-ylmethylsulfanyl)-1H-benzimidazole

: 913696-27-2
2-(((4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-benzimidazole

Guidance literature:: With potassium tert-butylate; In dimethyl sulfoxide; at 60 - 90 ℃; for 69h; Product distribution / selectivity;

Reference yield:

: 4728-12-5
2,2-dimethyl-5-hydroxymethyl-1,3-dioxane

: 913696-27-2
2-(((4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide / toluene / 6.25 h / Heating / reflux

2: sodium acetate / 6 h / 50 - 80 °C

3: sodium hydroxide; water / methanol / 6.75 h / 20 °C

4: triethylamine / tetrahydrofuran / 1.67 h / 1 - 3 °C

5: triethylamine / tetrahydrofuran / 64.33 h

With potassium hydroxide; sodium hydroxide; water; triethylamine; sodium acetate; In tetrahydrofuran; methanol; toluene;

Reference yield: 90.9%

: 913696-27-2
2-(((4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-benzimidazole

: sodium (R)-2-(4-[2,2-dimethyl-1,3-dioxan-5-yl] methoxy-3,5-dimethyl pyridin-2-yl) methylsulfinyl-1H-benzimidazole

Guidance literature:: 2-(((4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-benzimidazole; With water; In toluene; at 60 ℃; for 0.1h;

With diethyl (2R,3R)-tartrate; In toluene; for 0.633333h;

With titanium(IV) isopropylate; Cumene hydroperoxide; N-ethyl-N,N-diisopropylamine; more than 3 stages;