1-O-HEXADECYL-2-ACETYL-RAC-GLYCEROL

Base Information

• Chemical Name: 1-O-HEXADECYL-2-ACETYL-RAC-GLYCEROL
• CAS No.: 87233-21-4
• Molecular Formula: C21H42 O4
• Molecular Weight: 358.56
• Hs Code.: 2915390090
• Mol file: 87233-21-4.mol

Synonyms:1-O-Hexadecyl-2-O-acetylglycerol;2-Acetyloxy-3-hexadecyloxy-1-propanol

Chemical Property of 1-O-HEXADECYL-2-ACETYL-RAC-GLYCEROL

Chemical Property:

• PSA: 55.76000
• LogP: 5.40830
• Storage Temp.: −20°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-O-HEXADECYL-2-ACETYL-RAC-GLYCEROL

There total 3 articles about 1-O-HEXADECYL-2-ACETYL-RAC-GLYCEROL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

1-hexadecyl-2-acetyl-3-trimethylsilylglycerol → <2-Hexadecyloxy-1-(hydroxymethyl)ethyl> acetate (87233-21-4,99945-82-1)

Guidance literature:

With ammonium bifluoride; In methanol; for 3h;

DOI:10.1007/BF00780200

Reference yield:

3-(hexadecyloxy)-1,2-propanediol (6145-69-3) → <2-Hexadecyloxy-1-(hydroxymethyl)ethyl> acetate (87233-21-4,99945-82-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / Et₃N / toluene / 2 h

2: 95 percent / Et₃N / toluene / 3 h / -10 - 20 °C

3: 52 percent / ammonium bifluoride / methanol / 3 h

With ammonium bifluoride; triethylamine; In methanol; toluene;

DOI:10.1007/BF00780200

Reference yield:

1-hexadecyl-3-trimethylsilylglycerol → <2-Hexadecyloxy-1-(hydroxymethyl)ethyl> acetate (87233-21-4,99945-82-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / Et₃N / toluene / 3 h / -10 - 20 °C

2: 52 percent / ammonium bifluoride / methanol / 3 h

With ammonium bifluoride; triethylamine; In methanol; toluene;

DOI:10.1007/BF00780200

upstream raw materials:

3-(hexadecyloxy)-1,2-propanediol

Downstream raw materials:

3-O-hexadecyl-2-acetyl-sn-glycero-1-phosphocholine

Refernces