(4S,5R)-4-(fluoromethyl)-5-{4-[(fluoromethyl)thio]phenyl}-2-phenyl-4,5-dihydro-1,3-oxazole

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Chemical Name:(4S,5R)-4-(fluoromethyl)-5-{4-[(fluoromethyl)thio]phenyl}-2-phenyl-4,5-dihydro-1,3-oxazole
CAS No.:859520-23-3
Molecular Formula:C₁₇H₁₅F₂NOS
Molecular Weight:319.375
Hs Code.:

Synonyms:(4S,5R)-4-(fluoromethyl)-5-{4-[(fluoromethyl)thio]phenyl}-2-phenyl-4,5-dihydro-1,3-oxazole

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Chemical Property of (4S,5R)-4-(fluoromethyl)-5-{4-[(fluoromethyl)thio]phenyl}-2-phenyl-4,5-dihydro-1,3-oxazole

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Technology Process of (4S,5R)-4-(fluoromethyl)-5-{4-[(fluoromethyl)thio]phenyl}-2-phenyl-4,5-dihydro-1,3-oxazole

There total 2 articles about (4S,5R)-4-(fluoromethyl)-5-{4-[(fluoromethyl)thio]phenyl}-2-phenyl-4,5-dihydro-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 859520-25-5
(4S,5R)-4-(fluoromethyl)-5-[4-(methylsulfinyl)phenyl]-2-phenyl-4,5-dihydro-1,3-oxazole

: 859520-23-3
(4S,5R)-4-(fluoromethyl)-5-{4-[(fluoromethyl)thio]phenyl}-2-phenyl-4,5-dihydro-1,3-oxazole

Guidance literature:: (4S,5R)-4-(fluoromethyl)-5-[4-(methylsulfinyl)phenyl]-2-phenyl-4,5-dihydro-1,3-oxazole; With antimony(III) chloride; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at 20 ℃; for 17h; Heating / reflux;

With sodium hydrogencarbonate; In dichloromethane; water; Product distribution / selectivity;

Reference yield:

: 96795-24-3
D-(-)-threo-2-phenyl-4-(4-(methylthio)phenyl)-2-oxazole-5-methanol

: 859520-23-3
(4S,5R)-4-(fluoromethyl)-5-{4-[(fluoromethyl)thio]phenyl}-2-phenyl-4,5-dihydro-1,3-oxazole

Guidance literature:: D-(-)-threo-2-phenyl-4-(4-(methylthio)phenyl)-2-oxazole-5-methanol; With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at -30 - 20 ℃; for 48h;

With antimony(III) chloride; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In water-d2; at -30 - 20 ℃; for 66h;

With sodium hydrogencarbonate; In dichloromethane; water; at -30 ℃; pH=7; Product distribution / selectivity;

Reference yield:

: 859520-23-3
(4S,5R)-4-(fluoromethyl)-5-{4-[(fluoromethyl)thio]phenyl}-2-phenyl-4,5-dihydro-1,3-oxazole

: 859520-24-4
(4S,5R)-4-(fluoromethyl)-5-{4-[(fluoromethyl)sulfonyl]phenyl}-2-phenyl-4,5-dihydro-1,3-oxazole

Guidance literature:: (4S,5R)-4-(fluoromethyl)-5-{4-[(fluoromethyl)thio]phenyl}-2-phenyl-4,5-dihydro-1,3-oxazole; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 14h;

With sodium hydrogencarbonate; In dichloromethane; water;