(E)-(3S,4S)-1-Benzyloxy-3-(4-methoxy-benzyloxy)-8-(tetrahydro-pyran-2-yloxy)-6-triethylsilanyl-oct-6-en-4-ol

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Chemical Name:(E)-(3S,4S)-1-Benzyloxy-3-(4-methoxy-benzyloxy)-8-(tetrahydro-pyran-2-yloxy)-6-triethylsilanyl-oct-6-en-4-ol
CAS No.:612050-88-1
Molecular Formula:C₃₄H₅₂O₆Si
Molecular Weight:584.869
Hs Code.:

Synonyms:(E)-(3S,4S)-1-Benzyloxy-3-(4-methoxy-benzyloxy)-8-(tetrahydro-pyran-2-yloxy)-6-triethylsilanyl-oct-6-en-4-ol

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Chemical Property of (E)-(3S,4S)-1-Benzyloxy-3-(4-methoxy-benzyloxy)-8-(tetrahydro-pyran-2-yloxy)-6-triethylsilanyl-oct-6-en-4-ol

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Technology Process of (E)-(3S,4S)-1-Benzyloxy-3-(4-methoxy-benzyloxy)-8-(tetrahydro-pyran-2-yloxy)-6-triethylsilanyl-oct-6-en-4-ol

There total 3 articles about (E)-(3S,4S)-1-Benzyloxy-3-(4-methoxy-benzyloxy)-8-(tetrahydro-pyran-2-yloxy)-6-triethylsilanyl-oct-6-en-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: Triethyl-[(Z)-1-iodo-3-(tetrahydro-pyran-2-yloxy)-propenyl]-silane

: 612050-87-0
(S)-2-[(S)-3-Benzyloxy-1-(4-methoxy-benzyloxy)-propyl]-oxirane

: 612050-88-1
(E)-(3S,4S)-1-Benzyloxy-3-(4-methoxy-benzyloxy)-8-(tetrahydro-pyran-2-yloxy)-6-triethylsilanyl-oct-6-en-4-ol

Guidance literature:: With n-butyllithium; boron trifluoride diethyl etherate; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h;
DOI:10.1016/S0040-4039(03)01667-8

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 612050-88-1
(E)-(3S,4S)-1-Benzyloxy-3-(4-methoxy-benzyloxy)-8-(tetrahydro-pyran-2-yloxy)-6-triethylsilanyl-oct-6-en-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / NaH / dimethylformamide / 2 h / 0 °C

2: 71 percent / n-BuLi; BF₃*Et₂O / diethyl ether; tetrahydrofuran / 1 h / -78 °C

With n-butyllithium; boron trifluoride diethyl etherate; sodium hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(03)01667-8

Reference yield:

: (S)-3-Benzyloxy-1-(S)-oxiranyl-propan-1-ol

: 612050-88-1
(E)-(3S,4S)-1-Benzyloxy-3-(4-methoxy-benzyloxy)-8-(tetrahydro-pyran-2-yloxy)-6-triethylsilanyl-oct-6-en-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / NaH / dimethylformamide / 2 h / 0 °C

2: 71 percent / n-BuLi; BF₃*Et₂O / diethyl ether; tetrahydrofuran / 1 h / -78 °C

With n-butyllithium; boron trifluoride diethyl etherate; sodium hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(03)01667-8