diphenylmethyl (4S*,7S*)-6-benzyl-2-hydroxy-1-oxo-5-oxa-2,6-diazaspiro <3.4> octane-7-carboxylate

Base Information

• Chemical Name: diphenylmethyl (4S*,7S*)-6-benzyl-2-hydroxy-1-oxo-5-oxa-2,6-diazaspiro <3.4> octane-7-carboxylate
• CAS No.: 108634-92-0
• Molecular Formula: C₂₆H₂₄N₂O₅
• Molecular Weight: 444.487

Synonyms:diphenylmethyl (4S*,7S*)-6-benzyl-2-hydroxy-1-oxo-5-oxa-2,6-diazaspiro <3.4> octane-7-carboxylate

Chemical Property of diphenylmethyl (4S*,7S*)-6-benzyl-2-hydroxy-1-oxo-5-oxa-2,6-diazaspiro <3.4> octane-7-carboxylate

Chemical Property:

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Technology Process of diphenylmethyl (4S*,7S*)-6-benzyl-2-hydroxy-1-oxo-5-oxa-2,6-diazaspiro <3.4> octane-7-carboxylate

There total 7 articles about diphenylmethyl (4S*,7S*)-6-benzyl-2-hydroxy-1-oxo-5-oxa-2,6-diazaspiro <3.4> octane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

diphenylmethyl (4S*,7S*)-6-benzyl-2-benzyloxy-1-oxo-5-oxa-2,6-diazaspiro<3,4>octane-7-carboxylate (108634-91-9,108659-41-2) → diphenylmethyl (4S*,7S*)-6-benzyl-2-hydroxy-1-oxo-5-oxa-2,6-diazaspiro <3.4> octane-7-carboxylate (108634-92-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 0.5h; under 760 Torr;

DOI:10.1016/S0040-4020(01)87377-4

Reference yield:

N-benzyl hydroxylalmine (622-30-0) → diphenylmethyl (4S*,7S*)-6-benzyl-2-hydroxy-1-oxo-5-oxa-2,6-diazaspiro <3.4> octane-7-carboxylate (108634-92-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / calcium chloride / CHCl₃ / 4 h / Ambient temperature

2: 37 percent / CHCl₃ / 50 °C

3: 75 percent / H₂ / Pd-C / methanol / 0.5 h / 760 Torr

With hydrogen; calcium chloride; palladium on activated charcoal; In methanol; chloroform;

DOI:10.1016/S0040-4020(01)87377-4

Reference yield:

glyoxylic acid benzhydryl ester (20578-60-3) → diphenylmethyl (4S*,7S*)-6-benzyl-2-hydroxy-1-oxo-5-oxa-2,6-diazaspiro <3.4> octane-7-carboxylate (108634-92-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / calcium chloride / CHCl₃ / 4 h / Ambient temperature

2: 37 percent / CHCl₃ / 50 °C

3: 75 percent / H₂ / Pd-C / methanol / 0.5 h / 760 Torr

With hydrogen; calcium chloride; palladium on activated charcoal; In methanol; chloroform;

DOI:10.1016/S0040-4020(01)87377-4

upstream raw materials:

diphenylmethyl (4S*,7S*)-6-benzyl-2-benzyloxy-1-oxo-5-oxa-2,6-diazaspiro<3,4>octane-7-carboxylate

glyoxylic acid benzhydryl ester

N-benzyl hydroxylalmine

bis(diphenylmethyl) L-tartrate

Downstream raw materials:

diphenylmethyl (4S*,7S*)-6-benzyl-1-oxo-5-oxa-2,6-diazaspiro<3.4>octane-7-carboxylate

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