(E)-3-(4-Butyl-phenyl)-1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-propenone

Base Information

• Chemical Name: (E)-3-(4-Butyl-phenyl)-1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-propenone
• CAS No.: 1027587-90-1
• Molecular Formula: C₂₄H₂₈O₃
• Molecular Weight: 364.485

Synonyms:(E)-3-(4-Butyl-phenyl)-1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-propenone

Chemical Property of (E)-3-(4-Butyl-phenyl)-1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-propenone

Chemical Property:

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Technology Process of (E)-3-(4-Butyl-phenyl)-1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-propenone

There total 2 articles about (E)-3-(4-Butyl-phenyl)-1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)ethanone (16162-69-9) + 4-(n-butyl)benzaldehyde (1200-14-2) → (E)-3-(4-Butyl-phenyl)-1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-propenone (1027587-90-1)

Guidance literature:

With sodium hydroxide; In methanol; at 28 ℃;

DOI:10.1021/jm0101747

Reference yield:

4-Hydroxyacetophenone (99-93-4) → (E)-3-(4-Butyl-phenyl)-1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-propenone (1027587-90-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridinium p-toluenesulfonate / CH₂Cl₂ / 4 h / 20 °C

2: NaOH / methanol / 28 °C

With sodium hydroxide; pyridinium p-toluenesulfonate; In methanol; dichloromethane;

DOI:10.1021/jm0101747

Reference yield: 51.6%

(E)-3-(4-Butyl-phenyl)-1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-propenone (1027587-90-1) → (E)-3-(4-Butyl-phenyl)-1-(4-hydroxy-phenyl)-propenone (385810-21-9)

Guidance literature:

With hydrogenchloride; In ethanol; at 28 ℃; for 4h;

DOI:10.1021/jm0101747

upstream raw materials:

1-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)ethanone

4-(n-butyl)benzaldehyde

4-Hydroxyacetophenone

Downstream raw materials:

(E)-3-(4-Butyl-phenyl)-1-(4-hydroxy-phenyl)-propenone

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