5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(4-hydroxyphenyl)-4-methyl-1H-pyrazole-3-carboxamide

Base Information

• Chemical Name: 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(4-hydroxyphenyl)-4-methyl-1H-pyrazole-3-carboxamide
• CAS No.: 1334412-21-3
• Molecular Formula: C₂₃H₁₆Cl₃N₃O₂
• Molecular Weight: 472.758
• Mol file: 1334412-21-3.mol

Synonyms:5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(4-hydroxyphenyl)-4-methyl-1H-pyrazole-3-carboxamide

Chemical Property of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(4-hydroxyphenyl)-4-methyl-1H-pyrazole-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(4-hydroxyphenyl)-4-methyl-1H-pyrazole-3-carboxamide

There total 1 articles about 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(4-hydroxyphenyl)-4-methyl-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

4-amino-phenol (123-30-8) + ethyl 1-(2,4-dichlorophenyl)-4-methyl-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylate (158941-22-1) → 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(4-hydroxyphenyl)-4-methyl-1H-pyrazole-3-carboxamide (1334412-21-3)

Guidance literature:

With trimethylaluminum; In tetrahydrofuran; n-heptane; at 125 ℃; for 0.0583333h; Microwave irradiation;

DOI:10.1021/ml200091q

Reference yield: 86.0%

ethyl 2-bromoisobutyrate (600-00-0) + 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(4-hydroxyphenyl)-4-methyl-1H-pyrazole-3-carboxamide (1334412-21-3) → ethyl 2-(4-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamido)phenoxy)-2-methylpropanoate (1334412-22-4)

Guidance literature:

With potassium carbonate; In acetonitrile; at 90 ℃; for 16h;

DOI:10.1021/ml200091q

upstream raw materials:

4-amino-phenol

ethyl 1-(2,4-dichlorophenyl)-4-methyl-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylate

Downstream raw materials:

ethyl 2-(4-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamido)phenoxy)-2-methylpropanoate