N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(CH₂-CH₂-NH₂)-D-tryptophyl-L-leucine methyl ester hydrochloride

Base Information

• Chemical Name: N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(CH₂-CH₂-NH₂)-D-tryptophyl-L-leucine methyl ester hydrochloride
• CAS No.: 128746-02-1
• Molecular Formula: C₄₀H₅₀N₆O₇S*ClH
• Molecular Weight: 795.4

Synonyms:N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(CH₂-CH₂-NH₂)-D-tryptophyl-L-leucine methyl ester hydrochloride

Chemical Property of N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(CH₂-CH₂-NH₂)-D-tryptophyl-L-leucine methyl ester hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(CH₂-CH₂-NH₂)-D-tryptophyl-L-leucine methyl ester hydrochloride

There total 8 articles about N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(CH₂-CH₂-NH₂)-D-tryptophyl-L-leucine methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(CH2-CH2-NH-Boc)-D-tryptophyl-L-leucine methyl ester (128719-82-4) → N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(CH2-CH2-NH2)-D-tryptophyl-L-leucine methyl ester hydrochloride (128746-02-1)

Guidance literature:

With hydrogenchloride; ethane-1,2-dithiol; In acetic acid; for 1h; Ambient temperature;

Reference yield:

(R)-N-(benzyloxycarbonyl)phenylalanine N-hydroxysuccinimidyl ester (3397-36-2) → N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(CH2-CH2-NH2)-D-tryptophyl-L-leucine methyl ester hydrochloride (128746-02-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / Et₃N, H₂O / dimethylformamide / 120 h / Ambient temperature

2: 56 percent / dicyclohexylcarbodiimide (DCCI), 1-hydroxybenzotriazole (HOBt), Et₃N / dimethylformamide / 4 °C

3: 85 percent / 4N HCl, 1,2-dithioethane / acetic acid / 1 h / Ambient temperature

With hydrogenchloride; water; benzotriazol-1-ol; ethane-1,2-dithiol; triethylamine; dicyclohexyl-carbodiimide; In acetic acid; N,N-dimethyl-formamide;

Reference yield:

methyl (L)-leucinate hydrochloride (7517-19-3) → N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(CH2-CH2-NH2)-D-tryptophyl-L-leucine methyl ester hydrochloride (128746-02-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 85.9 percent / dicyclohexylcarbodiimide (DCCI), 1-hydroxybenzotriazole (HOBt), Et₃N / dimethylformamide / 4 °C

2: 83.6 percent / 6N HCl, dithioethane / ethyl acetate / 1 h

3: 56 percent / dicyclohexylcarbodiimide (DCCI), 1-hydroxybenzotriazole (HOBt), Et₃N / dimethylformamide / 4 °C

4: 85 percent / 4N HCl, 1,2-dithioethane / acetic acid / 1 h / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; ethane-1,2-dithiol; triethylamine; dicyclohexyl-carbodiimide; In acetic acid; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(CH₂-CH₂-NH-Boc)-D-tryptophyl-L-leucine methyl ester

(R)-N-(benzyloxycarbonyl)phenylalanine N-hydroxysuccinimidyl ester

methyl (L)-leucinate hydrochloride

2-amino-3-((2-((tert-butoxycarbonyl)amino)ethyl)thio)propanoic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 128746-02-1 N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(CH₂-CH₂-NH₂)-D-tryptophyl-L-leucine methyl ester hydrochloride

Send

Send

Metric Ton KG G Pound L ML

Send

Send